Universal transcriptome editing technologies

通用转录组编辑技术

• 批准号: LP210200888
• 负责人: Prof Oliver Rackham
• 金额: $ 44.04万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP210200888
• 关键词: Universal; transcriptome; editing; technologies

Ribonucleic acid (RNA) is life’s most essential molecule – as no living cell or virus can function without it. Although RNA plays many critical roles in cells, from information transfer and regulation of gene expression to scaffolding macromolecular structures and catalysis, the current approaches to manipulate RNA for technological purposes are limited in many respects. This project brings together the scientists who were the first to discover a universal code for recognition of RNA by proteins and one of the world’s leading RNA-focused biotechnology companies, Locana Biosciences, with the goal of providing robust and versatile tools to target RNA in diverse organisms.

核糖核酸（RNA）是生命中最重要的分子，因为没有它，任何活细胞或病毒都无法发挥作用。尽管RNA在细胞中扮演着许多关键的角色，从信息传递和基因表达的调节到支架大分子结构和催化，但目前用于技术目的的操纵RNA的方法在许多方面都受到限制。该项目汇集了第一批发现蛋白质识别RNA的通用代码的科学家和世界领先的专注于RNA的生物技术公司之一Locana Biosciences，其目标是提供强大而通用的工具来靶向不同生物体中的RNA。