Genetic selection of artificial polyketides

人工聚酮化合物的遗传选择

• 批准号: DP180101656
• 负责人: Prof Oliver Rackham
• 金额: $ 37.13万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-03-21 至 2022-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180101656
• 关键词: Genetic; selection; artificial; polyketides

This project aims to harness the potential of synthetic biology to build cells that can make valuable new derivatives of polyketides. Polyketides are natural products that have proven to be highly effective for use in industry, medicine and agriculture. The technologies developed in this project will provide resources to discover new chemicals, accessible to almost any scientific laboratory. Expected outcomes include the opportunity to put the future of natural product discovery and optimisation in the hands of the wider scientific community, which will provide significant benefits, such as providing new tools for Australian industries.

该项目旨在利用合成生物学的潜力来构建能够制造有价值的聚酮衍生物的细胞。聚酮类化合物是一种天然产物，已被证明在工业、医药和农业中都有非常有效的应用。在这个项目中开发的技术将为发现新化学物质提供资源，几乎任何科学实验室都可以使用。预期的结果包括有机会将天然产物发现和优化的未来交到更广泛的科学界手中，这将带来重大利益，例如为澳大利亚工业提供新工具。