Synthetic regulators of gene expression

基因表达的合成调节剂

• 批准号: DP140104111
• 负责人: Prof Oliver Rackham
• 金额: $ 36.22万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140104111
• 关键词: Synthetic; regulators; gene; expression

RNA plays many essential roles in cells, from information transfer and regulation of gene expression to scaffolding macromolecular structures and catalysis. Despite these realisations the current approaches to manipulate RNA are limited in many respects. This project will use synthetic biology approaches to engineer synthetic regulators of RNAs in living cells. These studies will provide new tools for use in biological research and provide insights into how natural proteins control gene expression. Furthermore, this project will use these tools to understand the mechanisms of how proteins are synthesised in mammalian mitochondria.

RNA在细胞中起着许多重要的作用，从信息传递和基因表达调控到支架大分子结构和催化。尽管有了这些认识，目前操纵RNA的方法在许多方面都是有限的。该项目将使用合成生物学方法来设计活细胞中rna的合成调节因子。这些研究将为生物学研究提供新的工具，并为了解天然蛋白质如何控制基因表达提供见解。此外，该项目将利用这些工具来了解哺乳动物线粒体中蛋白质合成的机制。