Screening of food stuffs, which stimulate NGF synthesis in brain

研究了不同氨基酸和蔬菜次生代谢产物对小鼠星形胶质细胞神经生长因子（NGF）合成的影响。l -色氨酸以剂量依赖的方式刺激NGF的产生。血清素和喹啉酸轻微增加NGF的合成。l -犬尿氨酸在100mum剂量下对NGF的合成有显著的刺激作用。相反，犬尿酸则没有作用。l -谷氨酰胺、谷氨酸、苯丙氨酸和蛋氨酸对培养的星形胶质细胞的NGF合成没有明显的影响。香豆酸、咖啡酸、咖啡因、绿原酸均未对细胞中神经生长因子的产生产生任何明显的变化。

Effects of various amino acids and secondery metabolites of vegetable foods were evaluated on synthesis of nerve growth factor (NGF) in cultured mouse astroglial cells. L-tryptophan stimulated NGF production in a dosedependent manner. Serotonin and quinolinic acid slightly increased NGF synthesis. L-Kynurenine had a marked stimulatory effect on NGF synthesis at a dose of 100 muM.In contrast, kynurenic acid had no effect. L-Glutamine, glutamic acid, phenylalanine, and methionine produced no appreciable change in NGF synthesis in cultured astroglial cells. None of coumaric acid, caffeic acid, caffeine, chlorogenic acid produced any appreciable change in NGF production in the cells.