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Continuous cardiac output measurements with a newly developed pulmonary artery Doppler catheter.

使用新开发的肺动脉多普勒导管连续测量心输出量。

基本信息

批准号：
05557068
负责人：
AKAMATSU Shigeru
金额：
$ 4.86万
依托单位：
Gifu University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05557068/
关键词：
Cardiac output Pulmonary artery catheter Doppler Velocity measurements Monitoring Ultrasound

项目摘要

Development of a method for continuous cardiac output measurements has been under way over a decade. Although intravascular ultrasound techniques have been used for measuring cardiac output continuously, a problem would be the angle of incidence between the ultrasound beam and the blood flow, which would constitute the errors in velocity measurements and in cardiac output measurements. We newly developed pulmonary artery Doppler catheter which could provide true flow velocity independent of the angle of incidence formed by the ultrasound beam and the flow.A pair of ultrasonic transducers positioned at a fixed angle was mounted on the distal section of pulmonary artery catheter to be positioned in the main pulmonary artery. The Doppler shifts (DELTAf1, DELTAF2) were detected by two transducers sampling at closely spaced two points in the main pulmonary artery. The values of DELTAF1 and DELTAf2 were used to compute two velocity measurements, and true flow velocity of pulmonary artery was … More calculated using following equation : V= ((V1)^2+(V2)^2)^<1/2>, where V=true velocity, V1 and V2=velocity detected by the transducer 1 and 2. The velocities were calculated using newly developed phase differential techniques. Cardiac output by thermodilution technique and true flow velocity of pulmonary artery were measured simultaniously. Then, cardiac output was calculated from true flow velocity of pulmonary artery continuously. After IRB approval, the pulmonary artery Doppler catheter (Aloka, Tokyo, Japan) was evaluated in animal experiments. The Doppler catheter was advanced to the pulmonary artery of anesthetized dogs (19-30kg). After thoracotomy, an electromagnetic flow probe was placed around the pulmonary artery. Cardiac output was measured by the pulmonary artery Doppler catheter (CO-Doppler), by thermodilution method (CO-Thermo) and by electromagnetic flowmeter (CO-EMF) simultaneously, and CO-Doppler, Co-Thermo and CO-EMF were compared.Co-Doppler was highly correlated with CO-EMF (Y=1.16x-0.27, r^2=0.99, n=71, p<0.001). CO-Doppler was also correlated with CO-Thermo (r^2=0.72).Using a newly developed pulmonary artery Doppler catheter, we are able to estimates cardiac output continuously. Our technique presented would be superior in measuring cardiac output at real time basis than other modified thermodilution techniques for continuous cardiac output monitoring. Less

连续心输出量测量方法的开发已经进行了十多年。尽管血管内超声技术已用于连续测量心输出量，但问题是超声波束和血流之间的入射角，这将构成速度测量和心输出量测量中的误差。我们新开发的肺动脉多普勒导管，可以提供与超声波束和血流形成的入射角无关的真实流速。一对以固定角度定位的超声换能器安装在肺动脉导管的远端部分，定位在主肺动脉中。多普勒频移（DELTAf1、DELTAF2）是通过在主肺动脉中间隔很近的两个点采样的两个换能器检测到的。使用 DELTAF1 和 DELTAf2 的值计算两个速度测量值，并使用以下公式计算肺动脉的真实流速：V= ((V1)^2+(V2)^2)^<1/2>，其中 V=真实速度，V1 和 V2=传感器 1 和 2 检测到的速度。使用新开发的相位计算速度微分技术。同时测量热稀释技术的心输出量和肺动脉真实流速。然后，根据肺动脉的真实流速连续计算心输出量。 IRB 批准后，肺动脉多普勒导管（Aloka，东京，日本）在动物实验中进行了评估。将多普勒导管推进至麻醉狗（19-30kg）的肺动脉。开胸手术后，将电磁流量探头放置在肺动脉周围。采用肺动脉多普勒导管（CO-Doppler）、热稀释法（CO-Thermo）和电磁流量计（CO-EMF）同时测量心输出量，并比较CO-Doppler、Co-Thermo和CO-EMF。Co-Doppler与CO-EMF高度相关（Y=1.16x-0.27，r^2=0.99， n=71，p<0.001）。 CO-Doppler 还与 CO-Thermo 相关 (r^2=0.72)。使用新开发的肺动脉多普勒导管，我们能够连续估计心输出量。我们提出的技术在实时测量心输出量方面优于其他用于连续心输出量监测的改良热稀释技术。较少的