Molecular mechanism of responses to stress in cardiovascular system

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Antithrombin III (AT-III), an anticoagulant, has recently been reported to directly affect human platelet functions. However, the exact mechanism of AT-III in platelets remains to be clarified. Our results strongly suggest that AT-III directly acts on platelets and suppresses ADP-induced platelet granule secretion such as platelet-derived growth factor-AB and serotonin due to inhibiting HSP27 phosphorylation via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase.