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HTLV-1 infection in Japan, Hawaii, and California: the effect of immigration from endemic southwestern Japan

日本、夏威夷和加利福尼亚州的 HTLV-1 感染：来自日本西南部流行病的移民的影响

基本信息

批准号：
05042003
负责人：
HINO Shigeo
金额：
$ 2.56万
依托单位：
Tottori University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1993
资助国家：
日本
起止时间：
1993 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05042003/
关键词：
ATL HTLV-1 Mother-to-child transmission Milk-borne infection Intrauterine infection PCR

项目摘要

a. SubjectsMain land US : Enrollment of subject from the REDS (SF area) study has begun. Of the 15 eligible REDS women, five have been enrolled thus far and 2 additional women have refused enrollment. The REDS enrollment at the three REDS blood banks which are RED Cross affiliated has been delayed by the necessity to obtain Human Subjects' approval by the central Red Cross Office. However, the REDS study Steering Committee has given approval to enrollment of the women, and the NIH project officer, George Nemo, Ph.D. has approved enrollment of subjects through the REDS mechanism. A total of eight other subjects has been identified at other Red Cross blood centers. The American Red Cross requires another approval by the central Red Cross Human Subjects' Committee before enrolling. This application was submitted in early January 1994, however, their committee meets only irregularly and a final approval has not yet been obtained. We expect such approval by the end of February.Hawaii : We h … More ave encountered delays in beginning enrollment at the Hawaii site due to the logistics of establishing the study infrastructure at this site distant from the Japanese and American primary investigators. However, the designation of Mary Flynn, M.D., the new Medical Director of the Blood Bank of Hawaii, as the person primarily responsible for the study has greatly facilitated these problems. Dr.Flynn has taken charge of the initial arrangements, including setting up of budgetary arrangements, and the designation of a skilled research technician who was recently laid off from the blood bank to perform the study enrollments. The study protocol is currently under review from the Human Subjects' Review Committee of the Blood Bank of Hawaii. As soon as this review is completed, we intend to begin enrollment of subjects. The updated total of HTLV-1 infected Japanese-American women eligible for the study in Hawaii is now 35. Nagasaki : Approval of the Human Right Committee of Nagasaki University has been obtained. Using ATL Prevention Program (APP) at Nagasaki, approximately 25 of 50 planned women have been already enrolled.b. Study Headquarters at UCSFProcedures for processing blood samples according to the red blood cell lysis protocol have been established and are in place both in Nagasaki and in San Francisco. It is planned that the other American sites will send their samples by overnight mail to the UCSF laboratory of Dr.Murphy for preservation of white blood cell pellets as well as plasma specimens. Additional preliminary studies on quantitative PCR on HTLV-1 specimens have been accomplished and show a correlation between HTLV-1 viral load and HTLV-1 antibody titer. Less

a.受试者美国本土：REDS（SF地区）研究的受试者入组已经开始。在15名符合资格的REDS妇女中，迄今已有5名登记，另有2名妇女拒绝登记。由于必须获得中央红十字会办公室的人类受试者批准，红十字会附属的三个REDS血库的REDS入组已被延迟。然而，REDS研究指导委员会已经批准了女性的入组，NIH项目官员乔治尼莫博士。已批准通过REDS机制入组受试者。在其他红十字会血液中心，总共确定了另外8名受试者。美国红十字会在注册之前需要中央红十字会人类受试者委员会的另一次批准。这项申请是在1994年1月初提出的，但是，他们的委员会只是不定期开会，尚未获得最后批准。我们预计在2月底前会获得批准。夏威夷：我们希望 ...更多信息在夏威夷研究中心，由于在该研究中心建立研究基础设施的后勤工作远离日本和美国的主要研究者，在开始入组时遇到了延迟。然而，玛丽弗林，医学博士，夏威夷血库的新医学主任，作为主要负责这项研究的人，极大地促进了这些问题的解决。弗林博士已负责初步安排，包括建立预算安排，并指定一名熟练的研究技术人员谁是最近下岗的血库进行研究登记。研究方案目前正在接受夏威夷血库人类受试者审查委员会的审查。一旦审查完成，我们计划开始入组受试者。在夏威夷，符合研究条件的HTLV-1感染日裔美国妇女的最新总数现在为35人。长崎：已获得长崎大学人权委员会的批准。在长崎，通过使用ATL预防方案，50名计划中的妇女中约有25名已经登记。UCSF的研究总部根据红细胞裂解方案处理血液样本的程序已经建立，并在长崎和旧金山弗朗西斯科实施。计划其他美国研究中心将通过隔夜邮件将其样本发送至Murphy博士的UCSF实验室，以保存白色血细胞团和血浆标本。对HTLV-1标本进行定量PCR的其他初步研究已经完成，并显示HTLV-1病毒载量和HTLV-1抗体滴度之间的相关性。少