HTLV-1 infection in Japan, Hawaii, and California: the effect of immigration from endemic southwestern Japan

A.科目主要地区美国：已开始招收红军(SF地区)研究科目。在15名符合条件的红军女性中，到目前为止已有5名女性被录取，另有2名女性拒绝录取。由于需要获得中央红十字会办公室的人体受试者批准，红十字会下属的三家红十字会血库的红军登记工作被推迟。然而，REDS研究指导委员会已经批准了这些女性的入学申请，NIH项目官员乔治·尼莫博士也批准了通过REDS机制招收受试者。其他红十字会血液中心共确认了八名受试者。美国红十字会在加入之前需要得到中央红十字会人类受试者委员会的另一次批准。这项申请是在1994年1月初提交的，然而，他们的委员会只是不定期开会，尚未获得最后批准。我们预计在2月底之前批准。夏威夷：We h…由于在远离日本和美国主要调查人员的地点建立研究基础设施的后勤工作，More Ave在夏威夷地点开始登记时遇到了延误。然而，夏威夷血库的新任医学主任玛丽·弗林被指定为这项研究的主要负责人，这大大促进了这些问题的解决。弗林博士负责最初的安排，包括建立预算安排，以及指定一名最近从血库下岗的熟练研究技术人员进行研究登记。该研究方案目前正在接受夏威夷血库人类受试者审查委员会的审查。一旦审查完成，我们打算开始招收科目。夏威夷有资格参加这项研究的感染HTLV-1的日裔美国妇女的最新总数现在为35人。长崎：已获得长崎大学人权委员会的批准。在长崎使用ATL预防方案(APP)，50名计划中的妇女中约有25人已经参加。加州大学旧金山分校的研究总部已经建立了根据红细胞裂解方案处理血液样本的程序，并在长崎和旧金山到位。按照计划，美国的其他地点将通过隔夜邮寄的方式将样本发送到墨菲博士的加州大学旧金山分校实验室，以保存白血球和血浆样本。对HTLV-1样本进行的定量PCR初步研究表明，HTLV-1病毒载量和HTLV-1抗体滴度之间存在相关性。较少

a. SubjectsMain land US : Enrollment of subject from the REDS (SF area) study has begun. Of the 15 eligible REDS women, five have been enrolled thus far and 2 additional women have refused enrollment. The REDS enrollment at the three REDS blood banks which are RED Cross affiliated has been delayed by the necessity to obtain Human Subjects' approval by the central Red Cross Office. However, the REDS study Steering Committee has given approval to enrollment of the women, and the NIH project officer, George Nemo, Ph.D. has approved enrollment of subjects through the REDS mechanism. A total of eight other subjects has been identified at other Red Cross blood centers. The American Red Cross requires another approval by the central Red Cross Human Subjects' Committee before enrolling. This application was submitted in early January 1994, however, their committee meets only irregularly and a final approval has not yet been obtained. We expect such approval by the end of February.Hawaii : We h … More ave encountered delays in beginning enrollment at the Hawaii site due to the logistics of establishing the study infrastructure at this site distant from the Japanese and American primary investigators. However, the designation of Mary Flynn, M.D., the new Medical Director of the Blood Bank of Hawaii, as the person primarily responsible for the study has greatly facilitated these problems. Dr.Flynn has taken charge of the initial arrangements, including setting up of budgetary arrangements, and the designation of a skilled research technician who was recently laid off from the blood bank to perform the study enrollments. The study protocol is currently under review from the Human Subjects' Review Committee of the Blood Bank of Hawaii. As soon as this review is completed, we intend to begin enrollment of subjects. The updated total of HTLV-1 infected Japanese-American women eligible for the study in Hawaii is now 35. Nagasaki : Approval of the Human Right Committee of Nagasaki University has been obtained. Using ATL Prevention Program (APP) at Nagasaki, approximately 25 of 50 planned women have been already enrolled.b. Study Headquarters at UCSFProcedures for processing blood samples according to the red blood cell lysis protocol have been established and are in place both in Nagasaki and in San Francisco. It is planned that the other American sites will send their samples by overnight mail to the UCSF laboratory of Dr.Murphy for preservation of white blood cell pellets as well as plasma specimens. Additional preliminary studies on quantitative PCR on HTLV-1 specimens have been accomplished and show a correlation between HTLV-1 viral load and HTLV-1 antibody titer. Less