Structure and function of the hippocampus

海马体的结构和功能

• 批准号: 05304058
• 负责人: OBATA Kunihiko
• 金额: $ 7.17万
• 依托单位: NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05304058/
• 关键词: hippocampus; development; fiber connection; glutamate receptor; long-term potentiation; kindling; memory; neuronal death; グルタミン酸受容体

Thirteen investigators in such various fields of neuroscience as neuroanatomy, neurophysiology, neuropharmacology, biophysics and neurosurgery jointed to advance our understanding of structure and function of the hippocampus which has been considered a key brain region for memory and other higher functions. Kawamura demonstrated expression of neurotrophic factors and their receptors and Ishizuka precisely disclosed afferent and efferent fiber connection. Ozawa and Okada investigated glutamate receptors and energy metabolism of hippocampal neurons. Kato, Satoh and Iijima studied mechanism of long-term potentiation electrophysiologically, pharmacologically and with optical recording, respectively, Obata showed molecular changes induced by kindling and kainate-induced seizure. Ono investigated hippocampus-related learning and memory in the monkey. Kataoka and Shigeno worked on the mechanism of glutamate-induced neuronal death. Kirino and Sato studied the mechanism of ischemia-induced cell death.

13位来自神经解剖学、神经生理学、神经药理学、生物物理学和神经外科学等神经科学领域的研究者联合起来，促进了我们对海马结构和功能的理解，海马被认为是记忆和其他高级功能的关键脑区。Kawamura证明了神经营养因子及其受体的表达，Ishizuka精确地揭示了传入和传出纤维连接。Ozawa和Okada研究了谷氨酸受体和海马神经元的能量代谢。Kato、Satoh和Iijima分别用电生理、电生理和光学记录等方法研究了长时程增强的机制，Obata在点燃和红藻氨酸诱导的癫痫发作中表现出分子变化。Ono研究了猴子与大脑相关的学习和记忆。Kataoka和Shigeno致力于谷氨酸诱导神经元死亡的机制。Kirino和Sato研究了缺血诱导细胞死亡的机制。

项目成果

Obata K.: "Impairment and recovery of spatial learning after partial loss of hippocampal CA1 neurons induced by kainic acid.21GC01:Biomed Res." 15. 61-64 (1994)

Obata K.：“红藻氨酸诱导的海马 CA1 神经元部分丧失后空间学习的损害和恢复。21GC01：Biomed Res。”

甘利俊一,酒田英夫 編 小野武年,西条壽夫,上野照子分担執筆: "「脳とニューラルネット」(分担項目:記憶における海馬体の役割)" 朝倉書店, 159 (1994)

甘利俊一和坂田英雄主编，小野武俊、西条久男、上野辉子合着：《‘大脑和神经网络’（参加者：海马结构在记忆中的作用）》朝仓书店，159（1994）

Ono T.et al: "Place and contingency differential responses of monkey septal neurons during conditional place-object discrimination." J.Neurosci.印刷中. (1995)

Ono T. 等人：“条件性地点-物体辨别过程中猴子间隔神经元的地点和偶然差异反应”，J. Neurosci，出版中。

石塚 典生: "海馬の細胞構築と神経結合" 神経研究の進歩. 38. 5-22 (1994)

Norio Ishizuka：“海马体的细胞结构和神经连接”神经学研究进展 38. 5-22 (1994)。

Taketoshi Ono(編): "Brain Meihanisms of Pevception and Memory" Oxford University Press, 692 (1993)

Taketoshi Ono（编辑）：“感知和记忆的大脑Meihanisms”牛津大学出版社，692（1993）