Biological and etiological study on Kaposi's sarcoma

卡波西肉瘤的生物学和病因学研究

• 批准号: 06041086
• 负责人: TORIYAMA Kan
• 金额: $ 6.59万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06041086/
• 关键词: Kaposi's sarcoma; Africa; pathogenesis; EB virus; AIDS; 地理病理学; 細胞起源

Our field research was based on the histopathological, epidemiological and virological examinations of surgical specimens, which were collected in the Histology Departments of three hospitals, the Rift Valley Provincial General Hospital in Nakuru, the Nyanza Provincial General Hospital in Kisumu and Uasin Gishu District Hospital in Eldoret, western part of Kenya.A Head Investigator and two Investigators visited each Hospitals and studied 25 cases of Kaposi's sarcoma (KS), 132 cases of pediatric Hodgkin's disease, Burkitt's lymphoma and otherdiseases, which might have pathogenetic similarities to KS.It is thought that AIDS has been spreading in the westrn part of Kenya since the middle of the 1980's. Our analysis of epidemiological transition of KS in this area before and after the middle of 1980's is the following : African endemic type KS,which has no relation ot HIV infection, has been rapidly replaced by AIDS-related KS.We examined KS specimens microscopically, ultrastructurally and immunohistochemically. According to the predominant histological features, three main patterns of growth were recognized, namely, granulation tissue-like, angioma/angiosarcoma-like and spindle-shaped cel/fibrosarcoma-like lesions. Among the three growth patterns, cellular atypism and mitotic figure were not prominent. Ongoing studies suggest that KS cells are derived from primitive mesenchymal cells which are originally found around the blood vessels and the appendages in the dermis and KS is a less aggressive disease rather than a malignant neoplasm.On virological study of KS,EBV-DNA was found in tissues from several pediatric lymph node type KSs and we are going on examinig to detect pathogenetic diferences between African endemic type KS and AIDS-related KS.

我们的实地研究是基于手术标本的组织病理学、流行病学和病毒学检查，这些标本是在三家医院的组织学部门收集的，这三家医院是纳库鲁的裂谷省总医院、基苏穆的尼扬扎省总医院和埃尔多雷特的瓦辛吉舒地区医院，一名首席研究员和两名研究员访问了每家医院，研究了25例卡波西肉瘤（KS），132例儿童霍奇金病，Burkitt淋巴瘤和其他疾病，可能与KS的发病机制相似。据认为，艾滋病自20世纪80年代中期以来一直在肯尼亚西部蔓延。本文分析了80年代中期前后该地区KS的流行病学转变：与HIV感染无关的非洲地方型KS迅速被与AIDS有关的KS所取代。根据主要的组织学特征，识别出三种主要的生长模式，即肉芽组织样、血管瘤/血管瘤样和梭形细胞/纤维肉瘤样病变。在三种生长方式中，细胞分裂和有丝分裂相不明显。目前的研究表明，KS细胞来源于原始间充质细胞，这些细胞最初发现于真皮中的血管和附属物周围，KS是一种侵袭性较低的疾病，而不是恶性肿瘤。在KS的病毒学研究中，在几种小儿淋巴结型KS的组织中发现了EBV-DNA，我们将继续检查以检测非洲地方型KS和AIDS相关KS之间的致病差异。

项目成果

H.Itakura and K.Toriyama: Springer-Verlag. Kaposi's sarcoma (in "Tropical Pathology", Doerr ana Seifer, ed.), 1247-1279 (1995)

H.Itakura 和 K.Toriyama：施普林格出版社。

A.M.Mwinymtwana, K.Toriyama, N.O.Kamidigo, H.Eto and H.Itakura: "The Pattern of pediatric Solid Malignat Tumori in Western Kenya, East Arrica, 1979-1994 : An analysis based on histopathological study" American Jaournal of Tropical Medicine and Hygiene. 54

A.M.Mwinymtwana、K.Toriyama、N.O.Kamidigo、H.Eto 和 H.Itakura：“1979-1994 年肯尼亚西部、东阿里卡儿童实体恶性肿瘤的模式：基于组织病理学研究的分析”美国热带医学杂志和