How AIDS influences on African Endemic Kaposi's sarcoma?

艾滋病如何影响非洲地方性卡波西肉瘤？

• 批准号: 09041188
• 负责人: TORIYAMA Kan
• 金额: $ 2.5万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09041188/
• 关键词: Tropical Africa; Kenya; Kaposi's sarcoma; AIDS; アフリカ; AIDS; 発癌ウィルス; 細胞起源

We studied an epidemiological transition of Kaposi's sarcoma (KS), covering three provinces, Western, Nyanza and Rift Valley Provinces in the western part of Kenya East Africa during the 18-year period between 1980 and 1997. It is generally accepted that AIDS epidemics has been spreading in this area since the middle of the 1980's. When comparing the results of geopathological study on KS before and after the AIDS epidemic; I . The frequency of KS among all malignant tumors has increased to 0.8'/, from 0.6'/, , 2. The male to female ratio of KS has shifted to 6:1 after AIDS epidemic from 9:1 before AIDS epidemic, 3. Two peaks of the age distribution of KS in the early childhood (around 5 years old) and the middle age group (over 50 years old) before AIDS epidemic have changed to three peaks, including the adolescent age group (20 - 30 years old) after AIDS epidemic, 4 The mean age of the KS patients has shifted to 36 years old after AIDS epidemic from 40 years old before AIDS epidemic, 5. The frequency of disseminated and aggressive form of KS with lymph node involvement among the adult patients has elevated after AIDS epidemic, 6. KS is rapidly spreading among the inhabitants in semi-arid areas and tropical highlands, where very few patients were found before AIDS epidemic. These findings suggest that AIDS-related KS has been increasing in number and spreading rapidly after AIDS epidemic in western part of Kenya. East Africa.

我们研究了1980年至1997年18年间卡波西肉瘤（KS）的流行病学变迁，覆盖了东非肯尼亚西部地区的西部省、尼安萨省和裂谷省三个省份。人们普遍认为，艾滋病流行自20世纪80年代中期以来一直在该地区蔓延。比较艾滋病流行前后KS的地质病理学研究结果时；我 。 KS在所有恶性肿瘤中的出现频率已从0.6'/增至0.8'/, 2. KS的男女比例由艾滋病流行前的9:1转变为艾滋病流行后的6:1, 3. KS的年龄分布从艾滋病流行前的幼儿期(5岁左右)和中年组(50岁以上)的两个高峰变为包括青少年年龄组(20岁以上)的三个高峰 - 艾滋病流行后 30 岁），4 艾滋病流行后 KS 患者的平均年龄由艾滋病流行前的 40 岁变为 36 岁，5. 艾滋病流行后，成年患者中播散性和侵袭性 KS 伴淋巴结受累的频率有所升高，6. KS 在半干旱地区和热带高地的居民中迅速传播，这些地区发现的患者很少 在艾滋病流行之前。这些发现表明，肯尼亚西部地区艾滋病流行后，与艾滋病相关的 KS 数量不断增加并迅速蔓延。东非。