Comparative study of ATL and HTLV-I Related Disorders

ATL 和 HTLV-I 相关疾病的比较研究

• 批准号: 06042010
• 负责人: TAKATUKI Kyoshi
• 金额: $ 4.48万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06042010/
• 关键词: HTLV-I; ATL; Epidemiology; China; Brazil; Henduras; Columbia; Mexico; HTLV-Iキャリア; HAM; TSP

Until now there is no any investigation of HTLV-I seroprevalence in risk populations in mainland of China. To know the seroprevalence of HTLV-I in risk populations in Tianjin, we performed the survey. We totally. collected 898 serum samples from leukemia, neurological diseases and hepatitis patients and blood donors. Only one patient's serum was positive for HTLV-I.The prevalence in risk groups from Tianjin, China, is low and comparable to other non-endemic countries. (China)We have investigated 27 HTLV-I asymptomatic carriers from Sao Paulo, with ophthalmological examinations searching for uveitis. The risk factors were multiple blood transfusions, intravenous drug use and infected mothers. We found corneal erosion and chorioretinal and cotton wool in 5 cases, the findings consistent with HTLV-I uveitis reported by Mochizuki et al. (Brazil)114 sera samples, 62 of black population, living in Puerto Cortes, Atlantic Coast and 52 of prostitutes living in San Pedro Sula were tested antibodies for HTLV-I/II.The prevalence of the black population is 17.7% and exclusively due to HTLV-I.The only case of HTLV-II infection came from a prostitute with no risk factor and HIV negative. (Honduras)We analyzed samples from a family (Amerindian descendants) that were born in Colombia's southern Andes near the city of Cali and are living in Cai. A 35-yrs-old woman donor was detected as a HTLV-I/II carrier in the blood bank. Her parents were also seropositive to HTLV-II.Those donors are asymptomatic and healthy, with a negative story of transfusion, surgery, tattoo, intravenous drugs, and/or migration to HTLV-II endemic areas. This familial case of HTLV-II infection permits us to speculate that horizontal transmission had occurred in the spouses, and vertical transmission occurred from mother to daughter. This is the first case of a HTLV-II carrier detected in blood bank screening. (Colombia)

到目前为止，尚无中国大陆高危人群HTLV-I血清患病率的调查。为了解天津市高危人群HTLV-I的血清患病率，我们进行了调查。我们完全。收集白血病、神经系统疾病、肝炎患者及献血者血清样本898份。只有一名患者血清HTLV-I阳性。中国天津危险人群的流行率较低，与其他非流行国家相当。（中国）我们调查了来自圣保罗的27例HTLV-I无症状携带者，眼科检查寻找葡萄膜炎。危险因素是多次输血、静脉注射药物和感染母亲。我们在5例患者中发现角膜侵蚀、脉络膜和棉球，结果与Mochizuki等人（巴西）报道的HTLV-I葡萄膜炎一致。我们检测了114份血清样本，62份生活在大西洋海岸Cortes港的黑人和52份生活在圣佩德罗苏拉的妓女的HTLV-I/II抗体。黑人人口的患病率为17.7%，完全由HTLV-I引起。唯一的HTLV-II感染病例来自一名无危险因素且HIV阴性的妓女。（洪都拉斯）我们分析了一个家庭（美洲印第安人后裔）的样本，该家庭出生在哥伦比亚南部安第斯山脉附近的卡利市，现居住在蔡。一名35岁女性献血者在血库中被检测为HTLV-I/II携带者。她的父母HTLV-II血清也呈阳性。这些献血者无症状且健康，有输血、手术、纹身、静脉注射药物和/或迁移到乙型肝炎流行地区的负面经历。这一家族性HTLV-II感染病例使我们推测配偶之间发生了水平传播，而母亲与女儿之间发生了垂直传播。这是血库筛查中首次发现HTLV-II型携带者。(哥伦比亚)

项目成果

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Ono A.等人：“HTLV-I 葡萄膜炎患者的 HTLv-I 亚型分析”Jpn.J.Cancer Res.85。

Takatsuki K.: "Adult T-cell leukemia" Oxford Medical Publications, 268 (1995)

Takatsuki K.：“成人 T 细胞白血病”牛津医学出版物，268 (1995)

A.Brank,K.: "HTLV-II detection in an amerindian family in colombian Southern Andean region" J.AIDS & Human Retrovirology. 10. 205-206 (1995)

A.Brank,K.：“在哥伦比亚南安第斯地区的一个美洲印第安家庭中检测到 HTLV-II” J.AIDS

S.Oguma: "Stable human T-lyphotropic virus type I carrier rates for seven years among a teenaged blood donor cohort of 1986 in Kumamoto,Japan" Leukemia Res.19. 567-571 (1995)

S.Oguma：“1986 年日本熊本的青少年献血者群体中，人类 T 淋巴细胞病毒 I 型携带率持续七年保持稳定”《白血病研究》19。

M.Tatewaki: "Constitutive overpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type I tax" Blood. 86. 3109-3117 (1995)

M.Tatewaki：“成人 T 细胞白血病的新鲜白血病细胞中 L-选择素基因的组成性过度抑制，可被人类 T 细胞嗜淋巴细胞病毒 I 型税反式激活”血液。