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Neuro-immuno-endocrinological aspects of pathophysiology of affective disorders

情感障碍病理生理学的神经免疫内分泌方面

基本信息

批准号：
06304033
负责人：
YAMAWAKI Shigeto
金额：
$ 7.49万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06304033/
关键词：
affective disorders immunology endocrinology antidepressant stress serptonin セロトニン

项目摘要

This study was undertaken to clarify the pathophysiology of affective disorders in view of neuro-immuno-endocrinology and found several facts as below mentioned.1.Blood flow rate of cortex was reduced in the patients with affective disorders using Xe-CT.2.In rat frontal cortex, antidpressants inhibited dopamine uptake.3.Learned helplessness may be a good model for depression.4.Trimethyltin altered the function of HPA-axis and behavior in rats.5.Stress to fatal rats changed the plasticity of neurons and endocirne response in rats.6.Interleukin-1 mediated the restraint stress-induced monoamine release in hypothalamus of rats.7.Psychiatric morbidity in cancer patients was investigated and it proved that 20-40 % of the cancer patients suffer from psychiatric problems.8.A novel antidepressant drug rolipram facilitated the function of Gs protein-cA MP production.9.Several antidepressant drugs and mood stabilizers inhibited intracellular chlcium increase induced by depolarization, some agonists and so on, in primary cultured neuronal cells.10.Antidepressant drugs modulated the phosphorylation and dephosphorylation of microtubule associated protein II.These results and the historical view of the biological investigations on affective disorders were collected, edited and published in a booknamed Neuro-Immuno-Endocrinology of Affective Disorders-New Direction to the Century of the Brain-.

本研究从神经免疫内分泌学角度探讨情感性精神障碍的病理生理机制，发现：1. Xe-CT显示情感性精神障碍患者大脑皮层血流速度减慢; 2.在大鼠额叶皮层，3.习得性无助可能是抑郁症的一个很好的模型。4.三甲基锡改变了HPA的功能。5.致死性应激改变了大鼠神经元的可塑性和内分泌反应; 6.白细胞介素-1介导了束缚应激诱导的大鼠下丘脑单胺释放; 7.调查了癌症患者的精神病发病率，证实20- 40%的癌症患者的精神病发病率高于对照组。新型抗抑郁药咯利普兰可促进Gs蛋白-cA MP的产生9.几种抗抑郁药和情绪稳定剂可抑制去极化引起的细胞内钙离子增加，10.抗抑郁药对微管相关蛋白II的磷酸化和去磷酸化的调节。这些结果和情感障碍生物学研究的历史观点被收集、编辑并发表在《情感障碍的神经免疫内分泌学--脑世纪的新方向》一书中。