Study on Emotional Neuroplasticity in the Pathophysiology of Affective Disorders

由于情绪神经可塑性被报道与情绪障碍的发病机制有关，我们在应激相关障碍的动物模型和抑郁症患者中研究了神经可塑性的机制1)应激诱导的神经可塑性的变化神经可塑性受神经营养因子调节的海马神经可塑性在情绪记忆的发展中发挥作用。我们检测了新生儿隔离(NI)或NI加单一束缚应激(SRS)是否改变了成年大鼠海马区几种神经营养因子的水平。NI组NGF、BDNF、GDNF、NT-3、IGFR1、IGFR2、IGFBP2mRNA水平无明显变化，NI+SRS显著下调GDNF、NGF、IGFR1、IGFBP2mRNA水平。这些发现表明，早期不良经历可能影响神经营养因素介导的海马神经可塑性的发展。2)单次持续应激大鼠恐惧和海马区基因表达的变化，PTSD到…的动物模型为了进一步阐明创伤后应激障碍的分子病理生理学机制，我们评估了恐惧条件反射后大鼠的情境冻结(CF)，并检测了SPS大鼠海马中参与CF变化的基因表达的变化。SPS大鼠肺泡泡相关膜蛋白2(VAMP2)的表达水平显著升高。3)抑郁症患者的情绪神经可塑性为了明确抑郁症患者和健康对照组之间情绪神经可塑性的差异，我们分析了磁脑图(MEG)所使用的感觉门控系统。结果表明，抑郁症患者情绪神经可塑性对感觉门控系统有不同的调节作用。这些结果表明，抑郁症患者的感觉门控系统受损可能与应激易感性有关，因为这可能是情感性障碍的风险。较少

Since emotional neuroplasticity is reported to be associated with the pathogenesis of mood disorders, we examined the mechanism of neuroplasticity in an animal model of stress-related disorders, and patients with depression.1)Stress-induced changes in neuroplasticityHippocampal neuroplasticity regulated by neurotrophic factors, plays a role in the development of emotional memory. We examined whether neonatal isolation (NI) or NI with a single restraint stress (SRS) changed the levels of several neurotrophioc factors in the adult rat hippocampus. Whereas NI had no changes in the levels of NGF,BDNF,GDNF,NT-3,IGFR1,IGFR2, or IGFBP2 mRNA, NI + SRS significantly downregulated the levels of GDNF,NGF,IGFR1, and IGFBP2 mRNA. These findings suggest that early adverse experience may affect the development of hippocampal neuroplasticity mediated by neurotrophic factors.2)Changes in fear and hippocampal gene expression in rats subjected to a single prolonged stress (SPS), an animal model of PTSDTo … More elucidate the molecular pathophysiology of PTSD, we assessed contextual freezing (CF) after fear conditioning and examined the change in hippocampal gene expression involved in the alteration of CF in rats subjected to SPS. The SPS rats showed a significant increase in CF, and cDNA microarray analysis revealed a significant increase in the levels of vesicle associated membrane protein 2(VAMP2). These findings suggest that VAMP2 may be involved in the enhanced CF in SPS rats.3)Emotional neuroplasticity in patients with depressionTo clear the difference for emotional neuroplasticity between depressive patients and healthy controls, we have analyzed the sensory gating system used by Magnetoencepharography(MEG). As a result, depressed patients had the different modulation in sensory gating system by emotional neuroplasticity. These results suggest that the broken sensory gating system in depressed patients might be correlated with vulnerability for stress as the risk for affective disorders. Less