Bone remodeling at the interface with biomaterials

与生物材料界面的骨重塑

• 批准号: 06404053
• 负责人: OKA Masanori
• 金额: $ 12.67万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06404053/
• 关键词: Bone; Remodeling; Biomaterials; Interface; FEM; stress; Wolff's law; 生体材料; 材料と骨とのインターフェイス; 関節軟骨の変化; 力学的刺激

Bone formation and remodeling around implanted materials are influenced by the kinds of materials, surface properties of the materials, anatomical sites of implantation, and the load-bearing condition. In this study, three kinds of materials were implanted into the femoral condyles of dogs, and bone formation and remodeling were observed for 6 months. Uniform thickening of lamellar bones was observed around bead-coated alumina while thick fibrous tissues surrounded by corticalized bones formed around smooth alumina. This distinct difference in remodeling pattern was subjected to mechanical simulation by using finite-element analysis (FEA) . Although stress distribution around bead-coated alumina simulates the bone density, the remodeling pattern around an uncoated implant could not be determined by the stress. To describe the latter remodeling pattern, it is necessary to analyze the strain surrounding the implants.

植入材料周围的骨形成和重建受材料种类、材料表面性质、植入解剖部位和承重条件的影响。本研究将三种材料植入犬股骨髁内，观察6个月的骨形成和改建情况。在珠粒涂层氧化铝周围观察到板层骨均匀增厚，而在光滑氧化铝周围形成被皮质化骨包围的厚纤维组织。通过有限元分析（FEA）对这种重塑模式的明显差异进行了力学模拟。尽管微珠涂层氧化铝周围的应力分布模拟了骨密度，但未涂层植入物周围的重塑模式无法通过应力确定。为了描述后一种重塑模式，有必要分析种植体周围的应变。

项目成果

M. Oka: "Bone remodeling around implanted materials" Clinical Biomechanics. 124-137 (1994)

M. Oka：“植入材料周围的骨重塑”临床生物力学。

S.Hanafusa: "Biodegradable plate fixation of rabbit femoral shaft osteotomies." Clin.Orthop.R.R.315. 262-271 (1995)

S.Hanafusa：“兔股骨干截骨术的可生物降解板固定。”

Y. Chang: "Significance of interstitial bone ingrowth under load-bearing conditions" 日整会誌. 69. 1661 (1995)

Y. Chang：“承重条件下间质骨向内生长的意义”日本学会杂志 69. 1661 (1995)。

岡正典: "関節軟骨のバイオメカニクス" 臨床リウマチ. 7. 60-81 (1995)

Masanori Oka：“关节软骨的生物力学”临床风湿病学 7. 60-81 (1995)。

T. Nakamura: "In vitro effects of EHDP on the foramtion and osteoclstic absorption of bone-like apatite formed on bioactive ceramics" Bioceramics. 8. 23-27 (1995)

T. Nakamura：“EHDP 对生物活性陶瓷上形成的骨状磷灰石的形成和破骨吸收的体外影响”生物陶瓷。