Development of artificial intervertebral disc

需要开发用于恢复脊柱的稳定性和可动性的人造椎间盘（AID）。由聚乙烯醇水凝胶（PVA-H）和钛纤维网（TFM）制成的复合材料作为人工骨-软骨材料似乎是AID的最佳候选材料。比较了PVA-H与犬椎间盘的各种力学性能，为椎间盘置换术的研制提供了基础数据。本研究中用于AID的H的含水量在30%和45%之间。我们将12个由上述材料制成的人工椎间盘植入12只比格犬的L4-L5椎间盘中。术后3个月的肉眼和显微镜检查结果显示，该材料与椎体的附着非常好，材料周围的组织学检查结果良好。总之，这种复合材料是非常有前途的候选人用于艾滋病。

Development of an artificial intervertebral disc (AID) for use in restoring both the stability and movability of the spine is desirable. The composite materials, made of polyvinyl alcohol hydrogels (PVA-H) and titanium fiber mesh (TFM) which we had developed as an artificial osteo-chondral material seems to be the best candidate for AID.In this study, we compared various mechanical properties of canine intervertebral disc and those of PVA-H in order to obtain fundamental data for development of AID.The best competent PVA-H for AID in this study had water content between 30% and 45%. We implanted 12 artificial intervertebral discs made of above-described material into L4-L5 intervertebral disc of 12 beagle dogs. Macroscopic and microscopic findings 3 months after the operations revealed very good attachment of this material to vertebral bodies and good histological findings around the materials. In conclusion, this composite material is very promising candidate for use in AIDs.