Development of artificial intervertebral disc

人工椎间盘的研制

• 批准号: 07557097
• 负责人: OKA Masanori
• 金额: $ 4.48万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557097/
• 关键词: Intervertebral disc; Mechanical properties; Artificial cartilage; Artificial porous bone; Replacement surgery for disc; 人工骨・軟骨複合材料; 脊椎のバイオメカニクス

Development of an artificial intervertebral disc (AID) for use in restoring both the stability and movability of the spine is desirable. The composite materials, made of polyvinyl alcohol hydrogels (PVA-H) and titanium fiber mesh (TFM) which we had developed as an artificial osteo-chondral material seems to be the best candidate for AID.In this study, we compared various mechanical properties of canine intervertebral disc and those of PVA-H in order to obtain fundamental data for development of AID.The best competent PVA-H for AID in this study had water content between 30% and 45%. We implanted 12 artificial intervertebral discs made of above-described material into L4-L5 intervertebral disc of 12 beagle dogs. Macroscopic and microscopic findings 3 months after the operations revealed very good attachment of this material to vertebral bodies and good histological findings around the materials. In conclusion, this composite material is very promising candidate for use in AIDs.

需要开发用于恢复脊柱的稳定性和可动性的人造椎间盘（AID）。由聚乙烯醇水凝胶（PVA-H）和钛纤维网（TFM）制成的复合材料作为人工骨-软骨材料似乎是AID的最佳候选材料。比较了PVA-H与犬椎间盘的各项力学性能，为椎间盘置换术的研制提供了基础数据。本研究中用于AID的H的含水量在30%和45%之间。我们将12个由上述材料制成的人工椎间盘植入12只比格犬的L4-L5椎间盘中。术后3个月的肉眼和显微镜检查结果显示，该材料与椎体的附着非常好，材料周围的组织学检查结果良好。总之，这种复合材料是非常有前途的候选人用于艾滋病。

项目成果

中西秀樹,岡 正典: "犬椎間板の特性について" 日本臨床バイオメカニクス学会誌. 16. 299-304 (1995)

Hideki Nakanishi、Masanori Oka：“犬椎间盘的特征”日本临床生物力学学会杂志 16. 299-304 (1995)。

由良茂人,岡正人: "人工椎間板の開発に関する研究(第1報)" 日整会誌. 69(8). S1604 (1995)

Shigeto Yura，Masato Oka：“人工椎间盘的发展研究（首次报告）”日本骨科杂志 69（8）（1995）。

真殿由美子,岡 正典: "人工椎間板に必要な力学的特性" 日本臨床バイオメカニクス学会. 17. 115-122 (1996)

Yumiko Madono、Masanori Oka：“人工椎间盘所需的机械特性”日本临床生物力学学会 17. 115-122 (1996)。

Y.Madono, M.Oka.: "Mechanical properties required for artificial intervertebral disc" J.Jap.Soc.Clin.Biomech.17. 115-122 (1996)

Y.Madono, M.Oka.：“人工椎间盘所需的机械特性”J.Jap.Soc.Clin.Biomech.17。

T.Hayami: "FEM studies of stress-distribution changes in trabecular architecture due to osteoarthritis of the hip." J. Kinki Univ. Mech. Eng.29. 25-29 (1995)

T.Hayami：“针对髋关节骨关节炎引起的小梁结构应力分布变化的有限元研究。”