Development of an Extracorporeal Circulation System with a Vibrating Flow Pump Driven Electromagnetically

为了开发一种高效的体外循环系统，利用振动流泵作为血泵进行了包括成年山羊动物实验在内的基础研究。该泵能在5-50赫兹的频率范围内产生符合典型正弦曲线的独特流型。本研究总结如下：1.成年山羊颈动脉和锁骨下动脉的流型、阻力和外周阻力随振动流泵驱动频率的不同而发生显着变化。这些结果表明，即使在相同的泵流量水平下，血流分布也是由人工心脏的驱动频率控制的。2.为了确定振荡血流对肺循环的影响，在成年山羊上进行了部分右心转流。肺动脉阻力和特征阻抗无明显变化。但在30赫兹血流时，它们略有增加。3.通过急性动物实验评价了膜式氧合器和振动流泵体外循环中氧气的传输速率。与离心泵型人工心脏和气动囊型人工心脏相比，人工心脏的氧气传输速率有所提高。4.研制了一种包括经皮电能传输系统在内的带有振动流动泵的全植入式脑室辅助系统。经皮能量传输系统的总效率为76%，在急性动物实验中温升在可接受的范围内。上述研究结果将为今后振动流泵体外循环系统的研究和开发提供有用的基础数据。

To develop a high-efficiency extracorporeal circulation system, basic research including animal experiments with adult goats has been performed with a vibrating flow pump as a blood pump. This pump can generate a unique flow pattern coincident with a typical sine curve in the frequency range of 5-50 Hz.The summary of this research is as follows :1.In adult goats the flow patterns and resistances of the carotid artery and the subclavian artery and the total peripheral resistance changed significantly according to the drive frequencies of the vibrating flow pump. These results suggest that blood flow distribution is controlled by the drive frequency of the artificial heart even during the same pump flow level.2.To determine the effect of the oscillated blood flow on pulmonary circulation, partial right heart bypass with the vebrating flow pump was performed in adult goats. Pulmonary arterial resistance and pulmonary arterial characteristic impedance were not significantly changed. But during 30 Hz flow, they were slightly increased. This suggests that the frequency of blood flow affects characteristics of pulmonary circulation.3.Oxygen transport rate during extracorporeal circulation with a membrane oxygenator and the vibrating flow pump was evaluated by acute animal experiments. It was found that the oxygen transport rate improved compared with that of the centrifugal pump type artificial heart and air-driven sac type one.4.A totally implantable ventricular assist system with a vibrating flow pump including a transcutaneous electric energy transmission system was developed. The total efficiency of the transcutaneous energy transmission system was 76%, and temperature increases were within the acceptable range in acute animal experiments. This suggests the usefulness of our newly developed system.The results described above will provide useful elementary data for future research and development of the extracorporeal circulation system with the vibrating flow pump.