DEVELOPMENT OF TREATMENT AGENT FOR HYPERSENSITIVE DENTIN BY DENTINE ADHESIVE POLYMERIC LATEX

牙本质黏附聚合乳胶牙本质过敏治疗剂的研制

• 批准号: 06557100
• 负责人: NAKABAYASHI Nobuo
• 金额: $ 2.62万
• 依托单位: INSTUTE FOR MEDICAL AND DENTAL ENGINEERING,TOKYO MEDICAL AND DENTAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557100/
• 关键词: DENTAL MMTERIALS; REACTIVE POLYMER; POLYMER EMULSION; HYPERSENSITIVE DENTIN; MMA-STYRENESULFONATECO POLYMER; DEPOSITION; 象牙質; 接着; ラテックス; 知覚過敏症; ポリスチレンスルホン酸; 反応性; ハイドロキシアパタイト; 被膜形成

Many treatment for hypersensitive dentin have been studying to obturate opened dentinal tubules. The occlusion of tubules can decrease the hydraulic conductance of dentin and relieve hypersensitivity. To develop a new treatment method for the hypersensitive dentine, an emulsion which can react with dentine at the surface and precipitate there was prepared. That is, a copolymer of methyl methacrylate (MMA) and p-stirene sulfonic acid (MS polymer). The MS polymer could react with dentin through ion bonding and deposit on the surface. A model dentin free of smear layr and plugs was directly treated with the emulsion (PMS) and the investigated with attention to the stability of the polymer membrane created on the dentin surface. Every treatment conditions with PMS was effective to obturate opened dentinal tubules, that is, the PMS was aggregated and made up a polymer film on model surface. The PMS treatment was the most high ability of occlusion of tubules under the durability tests. Though the dentinal tubules were observed clearly on the original model dentine, the treatment with PMS completely occluded these tubules by the deposition of PMS.Moreover, the PMS covered on the surface was not remove by the brushing. This founding indicated that the PMS could react with the dentin surface tightly. The main force of this stabilization is due to the ion bonding between sulfonate group and calcium ions originated form the dentin. The permeability of protons through the PMS layr was low and it is concluded that the PMS is one of the most effective materials for treatment of the hypersensitive dentin.

许多治疗过敏性牙本质的方法都是为了封闭开放的牙本质小管。封闭牙本质小管可降低牙本质的导水率，减轻牙本质过敏反应。为了探索一种治疗牙本质过敏症的新方法，制备了一种能与牙本质表面发生反应并在该处沉淀的乳剂。即，甲基丙烯酸甲酯（MMA）和对苯乙烯磺酸的共聚物（MS聚合物）。MS聚合物可与牙本质发生离子键合反应，并在牙本质表面形成存款。直接用该乳液（PMS）处理无玷污层和塞子的模型牙本质，并研究在牙本质表面上产生的聚合物膜的稳定性。PMS各处理条件均能有效封闭开放的牙本质小管，即PMS在模型表面聚集形成聚合物膜。在耐久性试验中，PMS处理的小管闭塞能力最高。尽管在原始模型牙本质上可以清晰地观察到牙本质小管，但PMS处理后牙本质小管被PMS沉积完全堵塞，而且覆盖在牙本质表面的PMS不能被刷牙去除。这一发现表明PMS可以与牙本质表面紧密结合。这种稳定作用的主要力量是源于牙本质中的钙离子与磺酸盐基团之间的离子键合。质子通过PMS层的渗透性较低，因此PMS是治疗牙本质过敏症的最有效材料之一。

项目成果

中林宣男: "反応性高分子と歯質との接着" 医器材研報. 29. 1-8 (1995)

Nobuo Nakabayashi：“反应性聚合物与牙齿结构之间的粘附”医疗设备研究报告 29. 1-8 (1995)。

中林宣男,藤井弁次,堀内博,石川烈,須田英明,山本隆司,細美靖和,戸井田哲也: "歯質反応性エマルジョンの象牙細管封鎖性-SEM観察による in vitro評価-" 日歯保誌. 38. 153 (1995)

Nobuo Nakabayashi、Benji Fujii、Hiroshi Horiuchi、R​​etsu Ishikawa、Hideaki Suda、Takashi Yamamoto、Yasukazu Hosomi、Tetsuya Toida：“牙本质反应性乳液的牙本质小管密封特性 - 通过 SEM 观察进行体外评估 -”Nippon Tooth Hoshi 38。 153 (1995)

N.NAKABAYASHI,B.FUJII,H.HORIUCHI,I.ISHIKAWA,H.SUDA,T.YAMAMOTO,Y.SAIMI,T.TOIDA19GC02 : J.J.CONST.DENT: 38 (6). 1538-1548 (1995)

N.Nakabayashi，B.FUJII，H.HORIUCHI，ISHIKAWA，H.SUDA，T.YAMAMOTO，Y.SAIMI，T.Toida19GC02：J.J.Const.DENT：38（6）。

山本隆司,細美靖和,中林宣男,藤井弁次: "歯質反応性エマルジョンの性質と象牙質知覚過敏抑制材料としてのin vitro評価" 歯材器. 14. 23 (1995)

Takashi Yamamoto、Yasukazu Hosomi、Nobuo Nakabayashi、Benji Fujii：“牙本质反应性乳液的特性以及作为抑制牙本质过敏材料的体外评价”Totsuki. 14. 23 (1995)。

T.YAMAMOTO,Y.SAIMI,N.NAKABAYASHI,B.FUJII: "PROPERTIES OF REACTIVE EMULSION WITH TOOTH AND IN VITRO EVALUATION FOR HYPERSENSITIVE DENTIN" J.J.DENT.MATER. 14. 54-55 (1995)

T.YAMAMOTO、Y.SAIMI、N.Nakabayashi、B.FUJII：“牙齿反应乳液的特性以及过敏性牙本质的体外评估”J.J.Dent.Mater。