Preparation and Pre-Clincal Evaluation of Novel Polymeric Dental Adhesives with Excellent Safty

安全性优异的新型高分子牙科粘合剂的制备及临床前评价

• 批准号: 02557075
• 负责人: NAKABAYASHI Nobuo
• 金额: $ 3.71万
• 依托单位: Tokyo Medical and Dental university
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02557075/
• 关键词: Dental Adhesive; Polymer; Reactivity; Graft Copolymer; Hydroxyapatite; Chelate Bond; 歯科接着材; 高分子電解質; 反応性高分子; pースチレンスルホン酸; 象牙質; エナメル質; 歯科用レジン

In order. to improved adhesion of dental resins onto teeth. polymeric adhesives were prepared and its application to the dental fields was evaluated. A water-soluble graft copolymers composed of p-styrene sulfonic acid and poly (methyl methacrylate) macromonomer (gMS) were synthesized. The teeth surface treated with gMS indicated similar polarity of poly (methyl methacrylate) even it was washed with water sufficiently. This finding means that the gMS reacted and covered on teeth surface. This is also confirmed by X-ray photoelectron spettroscopic analysis of the treated surface. The tensile bond strength of the dental resin to tooth enamel treated with the gMS aqueous solution was about 8MPa which is higher than the surface with the corresponding random copolymers of p-styrene bulfonate and mehtyl methac-rylate.

按顺序涉及改善牙科树脂在牙齿上的粘附性。制备了聚合物粘合剂并评价了其在牙科领域的应用。合成了对苯乙烯磺酸与聚甲基丙烯酸甲酯大分子单体（gMS）的水溶性接枝共聚物。用gMS处理的牙齿表面显示聚（甲基丙烯酸甲酯）的类似极性，即使用水充分洗涤。这一发现意味着GMS反应并覆盖在牙齿表面。这也证实了经处理的表面的X射线光电子能谱分析。经gMS水溶液处理后的牙釉质与树脂表面的拉伸粘结强度约为8 MPa，高于相应的对苯乙烯-甲基丙烯酸甲酯无规共聚物表面。

项目成果

Takashi Yamamoto, Junko Kajima, Kimio Kurita, Kazuhiko Ishihara, Nobuo Nakabayashi.: "Synthesis and Adhesin of Graft Copolymer with Reactive Group to Tooth Substrates" Kobunshi Ronbunshu. 49(2). 119-123 (1992)

Takashi Yamamoto、Junko Kajima、Kimio Kurita、Kazuhiko Ishihara、Nobuo Nakabayashi。：“具有反应基团的移植共聚物的合成及其对牙齿基质的粘附”Kobunshi Ronbunshu。

山本 隆司: "歯質反応性を有するグラフトコポリマ-の合成と歯質への接着性" 高分子論文集. 49. 119-123 (1992)

Takashi Yamamoto：“具有牙本质反应性和牙本质粘附力的接枝共聚物的合成”《聚合物科学与技术杂志》49. 119-123 (1992)。

山本 隆司: "スルホン酸基を有する高分子を利用した歯質と歯科用レジンの接着" 高分子論文集. 47. 655-658 (1990)

Takashi Yamamoto：“使用具有磺酸基团的聚合物粘合牙齿物质和牙科树脂”《聚合物科学与技术杂志》47. 655-658 (1990)。