Long-durable bonding of resin to dentin

树脂与牙本质的持久粘合

• 批准号: 09557151
• 负责人: NAKABAYASHI Nobuo
• 金额: $ 4.93万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09557151/
• 关键词: Dentin bonding; Hybridized dentin; Wet-bonding; Adhesion to dentin; Tensile test; Dumbbell; 歯科材料; 生体組織; 象牙質; コラーゲン; ハイドロキシアパタイト; 接着; 歯質; 歯科用材料; メタクリレート

Bonding of 4-methacryloyloxyethyl trimellitate anhydride in methyl methacrylate initiated by tri-n-butyl borane in the presence of poly(methyl methacrylate) (4-META/MMA-TBB resin) to dentin via hybridizatin of impregnated monomers that polymerize in situ was first described by Nakabayashi et al. in 1982. This concept was accepted in worldwide and many bonding systems were developed since then.Longevity of bonding is essential for dental treatments. Many dental people do not understand that demineralized dentin accepts hydrolysis in mouth event it is mainly composed of collagen. Complete hybridization is keen to provide long-durable bond to dentin but it has been difficult to eliminate the demineralized dentin. Monomer permeability of demineralized dentin is as important as diffusibility of monomers to dissolve this problem. The effects of etchants and/or primers on wet-bonding to dentin were examined. The morphological change of demineralized dentin after contact with chemicals was observed by atomic force microscope. The pretreatment of tooth substrate to obtain durable bonding to dentin was proposed in this research. We also advise that the bonding test using mini-dumbbell specimens is essential to identify defects in bonded specimens, which are impossible by conventional test specimens.

Nakabayashi等在1982年首次描述了在聚（甲基丙烯酸甲酯）（4-Meta/MMA-TBB树脂）存在下，由三正丁基硼烷引发的甲基丙烯酸甲酯中的4-甲基丙烯酰氧基乙基偏苯三酸酐通过原位交联的浸渍单体的杂化与牙本质的键合。这一概念在世界范围内被接受，并从那时起开发了许多粘结系统。粘结寿命对于牙科治疗至关重要。许多牙科工作者不了解脱矿牙本质在口腔中接受水解，而其主要成分是胶原蛋白。完全杂交能提供持久的牙本质结合，但很难消除脱矿牙本质。脱矿牙本质的渗透性与单体的扩散性一样重要，以解决这个问题。检查了蚀刻剂和/或底漆对牙本质湿粘结的影响。用原子力显微镜观察化学物质作用后脱矿牙本质的形态学变化。本研究提出了牙体基质的预处理方法，以获得与牙本质的持久粘接。我们还建议，使用迷你哑铃试样的粘接试验是必不可少的，以确定粘接试样中的缺陷，这是不可能的常规试样。

项目成果

G. Kato and N. Nakabayashi: "Effect of phosphoric acid concentration on wet-bonding to etched dentin"Dent Mater. 12. 250-255 (1996)

G. Kato 和 N. Nakabayashi：“磷酸浓度对蚀刻牙本质湿粘合的影响”Dent Mater。

N. Nakabayashi and Y. Saimi: "Bonding to Dentin"J Dent Res. 75. 1706-1715 (1996)

N. Nakabayashi 和 Y. Saimi：“与牙本质的结合”J Dent Res。

G.Kato and N.Nakabayashi: "Effect of phosphoric acid concentration on wet-bonding to etched dentin"Dent Mater. 12. 250-255 (1996)

G.Kato 和 N.Nakabayashi：“磷酸浓度对蚀刻牙本质湿粘合的影响”Dent Mater。

五十嵐賀世、戸井田哲也、中林宣男: "リン酸処理象牙質への接着におけるPhenyl-P/HEMAプライマー効果"歯科材料・器械. 16. 55-60 (1997)

Kayo Igarashi、Tetsuya Toida、Nobuo Nakabayashi：“Phenyl-P/HEMA 底漆对磷酸盐处理牙本质粘附的影响”《牙科材料和仪器》16. 55-60 (1997)。

N.Nakabayashi,A.Watanabe,and T.Arao: "A tensile test to facilitate identification of defects in dentine bonded speciments"Journal of Dentistry. 26. 379-385 (1998)

N.Nakabayashi、A.Watanabe 和 T.Arao：“有助于识别牙本质粘合样本缺陷的拉伸测试”牙科杂志。