New materials for artificial joint -Development of hydroxyapatite containing glass coated titanium composite-

人工关节新材料-含羟基磷灰石玻璃涂层钛复合材料的开发-

• 批准号: 06559008
• 负责人: IWATA Hisashi
• 金额: $ 5.12万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06559008/
• 关键词: Artificial joint; Hydroxyapatite; Titanium coposite; Glass; Bone-apatite interface; Bone formation; Bone absorption; 骨・アパタイト界面

It is well known that the hydroxyapatite (HA) is a bioactive ceramic having excellent biocompatibility with the body environment, and that pure titanium and titanium alloy such as Ti-6Al-4V with sufficient mechanical strength are suitable metals exhibiting good biological stability and affinity. In recent years, paticular attention has been drawn to the use of HA-coated implants for hip prostheses and a dental implants in which HA layr is coated on the surface of titanium substrate by plasma spraying, sputtering, hot pressing, and laser deposition, etc. Among these techniques, plasma spraying is a method commonly used in commercial products. However'there is a problem of change of chemical composition and structure due to the themal decomposition of HA under high temperature in plasma, and the HA coating layr with more than 50 mum in thickness behave like a brittle ceramic and leads to the peeling. Furthemore, the large difference in the linear thermal expansion coeffcient between the … More HA coating layr and the titanium or Ti-6Al-4V substrate can cause fatigue failure under tensile load.From the point of view, a HA containing glass coated titanium composite (HA-G-Ti composite) was developed with newly prepared glass and conventional enameling technique without using high temperatures such as plasma spraying. This composite consists of a substrate coated with a HA containing glass layr, wherein the layr comprises a continuous glass phase with dispersed HA particles and the surface is prepared in a roughened state. It has been found that the HA-G-Ti composite provides both bioactivity potential due to the HA and the mechanical strength of titanium, and the composites are useful for biocompatible composite materials which are especially suitable for implant applications. It is demonstrated that the physical properties of the HA containing glass with different concentration of HA are suitable to constitute the HA-G-Ti composite for bioactive implant and to make an excellent adhesion between the HA containing glass and the substrate. Less

众所周知，羟基磷灰石（HA）是一种生物活性陶瓷，与人体环境具有良好的生物相容性，具有足够机械强度的纯钛和钛合金如Ti-6Al-4V是表现出良好生物稳定性和亲和力的合适金属。近年来，HA涂层植入物在髋关节假体和牙科植入物中的应用引起了人们的特别关注，其中HA层通过等离子喷涂、溅射、热压和激光沉积等方法涂覆在钛基材表面上。在这些技术中，等离子喷涂是商业产品中常用的方法。然而，由于HA在等离子体中的高温下的热分解，存在化学组成和结构变化的问题，并且厚度大于50 μ m的HA涂层表现为脆性陶瓷并导致剥离。此外，在线性热膨胀系数之间的大的差异， ...更多信息 针对HA涂层与钛或Ti-6Al-4V基体在拉伸载荷下会产生疲劳破坏的问题，采用新制备的玻璃和传统的搪瓷工艺，在不使用等离子喷涂等高温处理的情况下，研制了一种含HA涂层的玻璃涂层钛基复合材料（HA-G-Ti复合材料）。该复合材料由涂覆有含HA的玻璃层的基材组成，其中该层包含具有分散的HA颗粒的连续玻璃相，并且表面以粗糙化状态制备。已经发现，HA-G-Ti复合材料由于HA而提供生物活性潜力和钛的机械强度，并且该复合材料可用于生物相容性复合材料，其特别适合于植入物应用。结果表明，不同HA含量的HA玻璃具有良好的物理性能，适合于制备生物活性植入体用HA-G-Ti复合材料，并使HA玻璃与基体之间具有良好的结合力。少

项目成果

S.Ban.Maruno,H.Iwata and H.Itoh.: "Calcium phosphate precipitation on the surface of HA-G-Ti composite under physiologic conditions." J.Biomed.Mater.Res.28. 65-71 (1994)

S.Ban.Maruno、H.Iwata 和 H.Itoh.：“生理条件下 HA-G-Ti 复合材料表面的磷酸钙沉淀。”

Takayasu Ito, Shinji Sakano, Keiji Sato, Hideshi Sugiura, Hisashi Iwata, Yoshiharu Murata and Hisao Seo: "Sensitivity of Osteoinductive Activity of Demineralized and Defatted Rat Femur to Temperature and Duration of Heating." Crin.Orthop.316. 267-275 (199

Takayasu Ito、Shinji Sakano、Keiji Sato、Hideshi Sugiura、Hisashi Iwata、Yoshiharu Murata 和 Hisao Seo：“脱矿和脱脂大鼠股骨的骨诱导活性对温度和加热持续时间的敏感性”。

S.Maruno,K.Imamura,T.Hanaichi,S.Ban,H.Iwata and H.Itoh.: "Characterization and Stability of Bioactivie HA-G-Ti Composite Materials and Bonding to Bone." Bioceramics. 7. 249-254 (1994)

S.Maruno、K.Imamura、T.Hanaichi、S.Ban、H.Iwata 和 H.Itoh.：“生物活性 HA-G-Ti 复合材料的表征和稳定性以及与骨的粘合。”

Keiko Yamamura, Hisashi Iwata, Takashi Osada, Kohji Yano, Toshihisa Yotsuyanagi and Toshitaka Nabeshima: "Prevention of bone loss by percutaneous estradiol implants in ovariectomized rats." J.Biomedical Materials Research. 29. 1249-1253 (1995)

Keiko Yamamura、Hisashi Iwata、Takashi Osada、Kohji Yano、Toshihisa Yotsuyanagi 和 Toshitaka Nabeshima：“通过经皮雌二醇植入卵巢切除大鼠来预防骨质流失。”

岩田 久,伊藤晴夫,石川知志,山田健志,丸野重雄: "ハイドロキシアパタイト含有ガラスチタン複合体の開発と人工関節への応用" Orthopaedics. 8. 13-19 (1995)

Hisashi Iwata、Haruo Ito、Satoshi Ishikawa、Kenji Yamada、Shigeo Maruno：“含羟基磷灰石玻璃钛复合材料的开发及其在人工关节中的应用”骨科。