Suppression of Right Ventricular Hypertrophy After Extensive Pulmonary Resection in Rats by Erythropoietin

本研究试图确定促红细胞生成素(EPO)对广泛肺切除术后肺动脉高压和右心衰竭的影响。将大鼠分为3组：(1)假手术组，单纯右开胸；(2)L组，右三叶切除，(3)EPO组，右三叶切除后皮下注射重组人EpoE。计算右室心肌细胞直径、右室/左室加室间隔重量比(RV/LV S；)。在这些结果中，EPO显著抑制右室肥厚。我们计算外周肺动脉内侧壁厚度的内径作为肺动脉高压的指标。EPO还能显著抑制外周肺动脉内膜厚度。

The present study sought to ascertain the effects of erythropoietin(Epo) on pulmonary hypertension and right heart failure following extensive pulmonary resection. Rats were divided into three group:(1)Group T, sham control comprising right thoracotomy only;(2)Group L, right three lobectomy;(3)Group EPO, right three lobectomy with subcutaneous administration of recombinant human EpoWe calculated diameter of right ventricular cardiomyocytes, weight ratio of the right ventricle to the left ventricle plus septum(RV/LV+S;). In these results, Epo significantly suppressed right ventricular hypertrophy. We calculated diameter of medial wall thickness of peripheral pulmonary arteries as an indicator of pulmonary hypertension. Epo also significantly su ppressed the medial wall thickness of peripheral pulmonary arteries.