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Physiological role of 20alpha-dihydroprogesterone during the estrous cycle in goats.

20α-二氢孕酮在山羊发情周期中的生理作用。

基本信息

批准号：
06660386
负责人：
SAWADA Tsutomu
金额：
$ 1.34万
依托单位：
Osaka Prefecture University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

项目摘要

(1) The relationships between the secretion of progesterone and 20alpha-dihydroprogesterone and the sites of their production in pregnant goats were investigated. These results suggest that in pregnant goats the main production site is the ovary for progesterone and the ovary and feto-placental unit for 20alpha-dihydroprogesterone, and 20alpha-dihydro-progesterone may take help to regulate progesterone production with in the ovary and the feto-placental unit. (Steroids 59 : 468-471,1994)(2) The secretion of progesterone and 20alpha-dihydroprogesterone during the estrous cycle and the effects of PGF2alpha and 20alpha-dihydroprogesterone on the secretion of these two steroids during the midluteal phase in goats were studied. These results indicate that in the goat after estrus, there is muchi 20alpha-dihydroprogesterone in the peripheral plasma. Progesterone may be catabolized to the biologically inactive steroid, 20alpha-dihydroprogesterone, during luteolysis. (Steroids 59 : 672-675,1994)(3) The relationships between the effects of single or repeated subcutaneous injections of progesterone on luteal function during the estrous cycle in goats as well as the secretion of 20alpha-dihydroprogesterone or PGFM,the major metabolite of PGF2alpha, were investigated. These results indicate that during the estrous cycle in goats, progesterone is catabolized to the biologically inactive steroid 20alpha-dihydroprogesterone, but much of the progesterone that is given early in the luteal phase of the estrous cycle causes premature luteolysis by stimulating an increase in the release of PGF2alpha. The secretion of 20alpha-dihydroprogesterone may help to regulate progesterone production during the estrous cycle in goats. (Theriogenology : in press)

(1)研究了妊娠山羊孕酮和20 α -二氢孕酮的分泌与产体部位的关系。上述结果提示，妊娠山羊孕酮的主要生产部位是卵巢，而20 -二氢孕酮的主要生产部位是卵巢和胎胎盘单元，20 -二氢孕酮可能有助于调节卵巢和胎胎盘单元中孕酮的生产。(2)研究了山羊发情周期中黄体酮和20 α -二氢孕酮的分泌情况，以及pgf2 α和20 α -二氢孕酮对黄体中期黄体酮和20 α -二氢孕酮分泌的影响。这些结果表明，发情后的山羊外周血中有大量的20 α -二氢孕酮。在黄体溶解过程中，黄体酮可能被分解为无生物活性的类固醇，20 α -二氢黄体酮。(3)研究了单次或多次皮下注射黄体酮对山羊发情周期黄体功能的影响，以及pgf2 α的主要代谢物- 20 α -二氢黄体酮或PGFM分泌的关系。这些结果表明，在山羊的发情周期中，黄体酮被分解代谢为无生物活性的类固醇20 α -二氢黄体酮，但在发情周期的黄体期早期给予的大部分黄体酮通过刺激pgf2 α释放的增加而导致过早的黄体溶解。20 α -二氢孕酮的分泌可能有助于调节山羊发情周期中孕酮的产生。（热遗传学：出版中）