Activation of tissue factor in MNMS due to acute arterial occlusion and its influence to genera organs

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Activation of tissue factor in MNMS due to acute arterial occlusion and its influence to general organs(1) Change of blood tissue factor level before and after aortic clamping in aortic aneurysm surgeryWe investigated the change of blood tissue factor level before and after aortic clamping in 6 cases of aortic aneurysm surgery. Blood tissue factor level of the first operative day was a little higher than that of pre-operative day, and then decreased on 3rd and 5th operative day. On 7th operative day, blood tissue factor level again increased and decreased on 14th operative day.(2) MNMS and remote organ failure due to the broad type of acute arterial occlusionIn acute arterial occlusion, the broad type in which ischemic change reached beyond the knee often compricates MNMS and has poor prognosis. Twenty-one cases of the broad type of acute arterial occlusion were studied. Five of seven cases who were alive complicated MNMS,but most of them had only renal failure. Eleven of fourteen cases who were dead complicated MNMS,and most of them had multiple organ failure.(3) Intestinal ischemia-reperfusion and pulmonary injuryWe investigated the pulmonary injury as a remote organ failure after intestinal ischemia-reperfusion using rat intestinal ischemia-reperfusion model. After 30-minute ischemia by clamping superior mesenteric artery, the change of pulmonary weight was measeured. After ischemia-reperfusion, pulmonary weight/body weight increased significantly. It is suggested that pulmonary edema may occur after intestinal ischemia-reperfusion.