Activation of tissue factor in MNMS due to acute arterial occlusion and its influence to genera organs

急性动脉闭塞所致MNMS组织因子的激活及其对各脏器的影响

• 批准号: 06671195
• 负责人: KANEKO Hirochi
• 金额: $ 1.34万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671195/
• 关键词: acute arterial occlusion; MNMS; tissue factor; ischemia-reperfusion

Activation of tissue factor in MNMS due to acute arterial occlusion and its influence to general organs(1) Change of blood tissue factor level before and after aortic clamping in aortic aneurysm surgeryWe investigated the change of blood tissue factor level before and after aortic clamping in 6 cases of aortic aneurysm surgery. Blood tissue factor level of the first operative day was a little higher than that of pre-operative day, and then decreased on 3rd and 5th operative day. On 7th operative day, blood tissue factor level again increased and decreased on 14th operative day.(2) MNMS and remote organ failure due to the broad type of acute arterial occlusionIn acute arterial occlusion, the broad type in which ischemic change reached beyond the knee often compricates MNMS and has poor prognosis. Twenty-one cases of the broad type of acute arterial occlusion were studied. Five of seven cases who were alive complicated MNMS,but most of them had only renal failure. Eleven of fourteen cases who were dead complicated MNMS,and most of them had multiple organ failure.(3) Intestinal ischemia-reperfusion and pulmonary injuryWe investigated the pulmonary injury as a remote organ failure after intestinal ischemia-reperfusion using rat intestinal ischemia-reperfusion model. After 30-minute ischemia by clamping superior mesenteric artery, the change of pulmonary weight was measeured. After ischemia-reperfusion, pulmonary weight/body weight increased significantly. It is suggested that pulmonary edema may occur after intestinal ischemia-reperfusion.

组织因子在急性动脉闭塞所致多发性骨髓瘤中的激活及其对全身器官的影响（1）主动脉瘤手术夹闭主动脉前后血液组织因子水平的变化我们观察了6例主动脉瘤手术夹闭主动脉前后血液组织因子水平的变化。手术第1天血液组织因子水平略高于术前，手术第3天、第5天下降。术后第7天，血组织因子水平再次升高，术后第14天下降。(2)广泛型急性动脉闭塞导致的MNMS和远端器官衰竭在急性动脉闭塞中，缺血性改变超过膝关节的广泛型常合并MNMS，预后差。本文报告21例宽型急性动脉闭塞。存活7例中5例合并MNMS，但多为单纯肾功能衰竭。14例死亡病例中11例并发MNMS，多为多器官功能衰竭。(3)肠缺血-再灌注与肺损伤采用大鼠肠缺血-再灌注模型，研究肠缺血-再灌注后肺损伤作为远隔器官功能衰竭。夹闭肠系膜上上级动脉30分钟后，测定肺重量的变化。缺血再灌注后肺重/体重显著增加。提示肠缺血再灌注后可发生肺水肿。