Optical Analysis of Distributed Processing in Neural Systems

神经系统分布式处理的光学分析

• 批准号: 07044231
• 负责人: KAMINO Kohtaro
• 金额: $ 8.32万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07044231/
• 关键词: central nervous system; distributed system; optical recording; brainstem; spinal cord; Aplysia; enteric plexus; hypothalamus; 腸管神経叢; 神経系; 分散処理システム; 光学的測定; 脳幹神経核; アプリシア神経節

This project is aimed at revealing the basic mechanisms of the "distributive processing" in the nervous system, and is organized as the international collaboration of three research groups which have a common technique for optical recording of neuronal activities using voltage-sensitive dyes. From 1995 to 1997, following studies have been carried out.1. K.Kamino's group :(1) The ontogenic organization of spatiotemporal patterns of neuronal activities in the nuclei of the brainstem (nucleus tractus soritarii, dorsal motor nerve of the vagus nerve, and nucleus ambiguus) of the embryonic chick and rat were analyzed from the view point of "distributive processing".(2) The functional organization of the spinal cord of the chick embryo was also studied. (This study was related that of L.B.Cohen's group.)2. L.B.Cohen's group :(1) The distributive processing mechanism in the abdominal ganglion of Aplysia was studied.(2) The fining pattern of the motor neurons of the embryonic chick spinal cord was analyzed. (This study was related to that of K.Kamino's group as started above.)(3) The spreading pattern and distributive processing of the neural information in the turtle visual cortex were studied.3. B.M.Salzberg's group :(1) Neuronal activities of the submucous plexus of guinea pig small intestine were recorded optically from several ganglia, and the inter-neuronal and inter-ganglionic distributive processing of neuronal information was analyzed.(2) The distributive processing of excitation-secretion coupling of mouse hypothalamo-pituitary system was studied.

该项目旨在揭示神经系统中“分布式处理”的基本机制，由三个研究小组组成的国际合作组织，这些研究小组拥有使用电压敏感染料光学记录神经元活动的通用技术。从1995年到1997年，进行了以下研究。（1）从“分布加工”的观点分析了鸡胚和大鼠胚脑干核团（背束核、迷走神经背运动神经和疑核）神经元活动时空模式的个体发生性组织。(2)本文还对鸡胚脊髓的功能组织进行了研究。(This（L.B.Cohen的研究）2.（1）研究了腹神经节的分布加工机制。(2)本文分析了鸡胚脊髓运动神经元的细化模式。(This该研究与上文开始的K.Kamino小组的研究有关。(3)研究了神经信息在乌龟视皮层的传播方式和分布加工.（1）从几个神经节光学记录豚鼠小肠粘膜下神经丛的神经元活动，分析神经元信息在神经元间和神经节间的分布加工。(2)本文研究了小鼠下丘脑-垂体系统兴奋-分泌偶联的分布过程。

项目成果

Sato,K.: "Optical mapping of neural responses in the embryonic rat brainstem: early functional organization of vagal nuclei In"Frontiers of Neural Development"" Springer-Verlag,Tokyo(in press), (1998)

Sato,K.：“胚胎大鼠脑干中神经反应的光学映射：迷走神经核的早期功能组织在“神经发育的前沿”中”Springer-Verlag，东京（印刷中），（1998）

Momose-Sato,Y.: "Evaluation of optimal voltage-sensitive dyes for optical monitoring of embryonic neural activity." The Journal of Membrane Biology. 144. 167-176 (1995)

Momose-Sato，Y.：“评估用于光学监测胚胎神经活动的最佳电压敏感染料。”

佐藤容子: "膜学実験シリーズ第1巻 生体膜編" 共立出版、東京, 424 (1993)

佐藤洋子：“膜科学实验系列第 1 卷：生物膜版”Kyoritsu Shuppan，东京，424 (1993)

Sakai, T.: "Optical monitoring of synaptic transmission in bullfrog symathetic ganglia using a voltage sensitive dye." Neuroscience Letters. (in press). (1998)

Sakai, T.：“使用电压敏感染料对牛蛙交感神经节中的突触传递进行光学监测。”

Momose-Sato Y,Sato K,sakai T,Hirota A and Kamino K: A novel GABA response identified optically in the nucleus of the tractus solitarius of the chick embryo.In "GABA : Receptots, Transporters and Metabolism". (ed.) Tanaka C and Bowery N G,Birkaeuser Verlag

Momose-Sato Y、Sato K、sakai T、Hirota A 和 Kamino K：在鸡胚孤束核中光学鉴定的新型 GABA 反应。在“GABA：受体、转运蛋白和代谢”中。