Development of Vaccine againest New Serotype O139 Bengal of Vibrio cholerae

O139孟加拉型霍乱弧菌是一种新的霍乱弧菌血清型，于1992年在印度首次分离出来，并于1993年上半年在整个印度次大陆蔓延。然而，在1993年下半年，霍乱弧菌占主导地位，1994年和1995年，从印度次大陆霍乱患者身上分离出的大多数霍乱弧菌是霍乱弧菌。1996年秋，我们在印度加尔各答目睹了O139霍乱弧菌的死灰复燃。霍乱弧菌血清型变化的流行病学调查为开发O139霍乱弧菌候选疫苗提供了重要信息。对O1型霍乱弧菌和O139型霍乱弧菌的遗传分析表明，1994-1995年分离的O1型霍乱弧菌与O139型霍乱弧菌的RFLP相似，但与1993年O139型霍乱弧菌出现前分离的O1型霍乱弧菌的RFLP不一致。

Vibrio cholerae O139 Bengal, a new serotype of cholerae vibrio, was first isolated in 1992 in India and it spread all over the Indian subcontinent during the first half of the year 1993. However, during the second half of 1993, V.cholerae O1 dominated and, in 1994 and 1995, most of V.cholerae isolated from cholera patients in the Indian subcontinent were V.cholerae O1. In the fall of 1996, we witnessed the resurgence of V.cholerae O139 Bengalin Calcutta, India.Epidemiological survey of such a change of serotypes of V.cholerae provided an important information to develop a candidate vaccine against V.cholerae O139.Genetic analysis of V.cholerae O1 and O139 showed that strains of V.cholerae O1 isolated during 1994-1995 resembled in their RFLP patterns to those of V.cholerae O139 but not to those of V.cholerae O1 isolated before the emergence of V.cholerae O139 on 1993.