Development of Therapeutic Evaluation in Cardio-and Cerebrovascular Disease by Using Positron Emission Tomography

应用正电子发射断层扫描（PET）技术对心脑血管疾病的疗效评价具有重要意义。合作研究者开发了与治疗效果相关的新评价方法。本研究主要完成了以下几个方面的工作：1.研制了新的心、脑血管疾病PET示踪剂。在此基础上，我们利用动物模型进行了代谢和受体定位的基础研究（Maeda和Watanabe）。2.我们对缺血性心脏病和心力衰竭患者进行了心脏PET研究。我们用正电子发射计算机断层扫描（PET）研究了经皮冠状动脉成形术和β受体阻滞剂治疗对心肌缺血和存活的影响<18><13><11>。3.我们对脑血管病和痴呆患者进行了脑PET研究。我们从脑血流和代谢的角度，用H_2^ O和气体研究来论证搭桥手术和抗痴呆治疗的疗效<15>（Sasaki和Yonekura）。4.我们开发了一种新的治疗效果评估系统，代谢与受体我们的研究表明，PET研究在评价心血管治疗效果方面具有重要意义。从基础研究和临床应用的角度来看，脑血管疾病是非常有用的。

It is important to evaluate therapeutic effects in cardio-and cerebrovascular disease by using positron emission tomography (PET). The co-investigators developed the new evaluation method related to the therapeutic effects. In this study, we completed the following items.1.We developed new PET tracers for cardio and cerebrovascular disease. Based on these data, we performed basic research using animal model for metabolic and receptor mapping (Maeda and Watanabe).2.We performed cardiac PET study in patients with ischemic heart disease and heart failure. We demonstrated the therapeutic effects of percutaneous transcatheter coronary angioplasty and beta-blocker therapy from the viewpoint of myocardial ischemia and viability by using ^<18>F-FDG,^<13>NH_3 and ^<11>C-acetate PET study (Ochi and Konishi).3.We performed brain PET study in patients with cerebrovascular disease and dementia. We demonstrated the therapeutic effects of bypass surgery and anti-dementia therapy from the viewpoint of cerebral blood flow and metabolism by using H_2^<15>O and gas study (Sasaki and Yonekura).4.We developed a new evaluation system of therapeutic effects by quantitative PET parameters related to flow, metabolism and receptor (Nishimura and Uehara).Our study demonstrated that PET study in evaluating the therapeutic effects of cardio-and cerebrovascular disease in very useful from the viewpoint of basic research and clinical application.