Development of Therapeutic Evaluation in Cardio-and Cerebrovascular Disease by Using Positron Emission Tomography

正电子发射断层扫描(PET)对心脑血管疾病的疗效评价具有重要意义。合作研究人员开发了与治疗效果相关的新评估方法。在本研究中，我们完成了以下工作：1.研制了心脑血管疾病的新型PET示踪剂。基于这些数据，我们使用代谢和受体定位的动物模型(前田和渡边)进行了基础研究。2.我们对缺血性心脏病和心力衰竭患者进行了心脏PET研究。我们用~(18)&gt；F-FDG，~(13)&gt；NH_3和~(11)&gt；C-醋酸酯PET研究(Ochi和Konishi)，从心肌缺血和存活的角度论证了经皮冠状动脉成形术和β-受体阻滞剂治疗的疗效。我们从脑血流和代谢的角度论证了搭桥手术和抗痴呆治疗的疗效，使用H_2^&lt；15&gt；O和GAS研究(Sasaki和Yonekura)。4.我们建立了一种新的通过与血流、代谢和受体(Nishimura和Uehara)相关的定量PET参数来评价疗效的系统。

It is important to evaluate therapeutic effects in cardio-and cerebrovascular disease by using positron emission tomography (PET). The co-investigators developed the new evaluation method related to the therapeutic effects. In this study, we completed the following items.1.We developed new PET tracers for cardio and cerebrovascular disease. Based on these data, we performed basic research using animal model for metabolic and receptor mapping (Maeda and Watanabe).2.We performed cardiac PET study in patients with ischemic heart disease and heart failure. We demonstrated the therapeutic effects of percutaneous transcatheter coronary angioplasty and beta-blocker therapy from the viewpoint of myocardial ischemia and viability by using ^<18>F-FDG,^<13>NH_3 and ^<11>C-acetate PET study (Ochi and Konishi).3.We performed brain PET study in patients with cerebrovascular disease and dementia. We demonstrated the therapeutic effects of bypass surgery and anti-dementia therapy from the viewpoint of cerebral blood flow and metabolism by using H_2^<15>O and gas study (Sasaki and Yonekura).4.We developed a new evaluation system of therapeutic effects by quantitative PET parameters related to flow, metabolism and receptor (Nishimura and Uehara).Our study demonstrated that PET study in evaluating the therapeutic effects of cardio-and cerebrovascular disease in very useful from the viewpoint of basic research and clinical application.