Three-dimensional analysis for pathological fracture risk iee sment in bone metastasis by PET/CT

PET/CT三维分析骨转移病理性骨折风险评估

• 批准号: 18591361
• 负责人: NISHIMURA Tsunehiko
• 金额: $ 2.2万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591361/
• 关键词: Bone metastasis; Pathological fracture; Multi-slice CT; PET; CT

Simulation by finite element analysis for fracture risk assessment in osteoporosis has been established, and the accurate displaying of the cancellous bone trabecular structure to evaluate bone quality by high-resolution micro-CT has been attempted. However, its application to cancer patients is difficult because it requires imaging over a wide area. Assessment of fractures should be based on mechanical analysis, and 3-dimensional analysis is also necessary. We firstly aimed at establishing a practical method to analyze metastatic bone, for which no analytical method for fracture assessment has been established because of variation in the properties.The subjects were 4 patients with different patterns of bone metastasis and could be followed up by CT without marked progression of the disease condition after radiotherapy. A finite element model of the bone was prepared from the clinical CT image, and analyzed using software, MECHANICAL FINDERョ, which is capable of integrative image proc … More essing and mechanical analysis. The vertebral regions were extracted from the obtained image. The outward form data were prepared, setting the basic mesh size to 2 mm, and a solid tetrahedral element was automatically produced. Regarding the analytical conditions, the bottom surface of the vertebral body was completely restrained, the weight-bearing area was homogenously set on the upper surface of the vertebral body, and the weight was vertically loaded in the axial direction. A 600N force was loaded on elasticity analysis, and a 1000N force on non-linear fracture line-predictive analysis.No fracture-predictive finding was obtained by any analysis of osteosclerotic bone metastasis, whereas the occurrence of fracture was predicted in osteolytic bone metastasis. The predicted region was not necessarily proximal to the bone metastatic lesion, suggesting the influence of the shape and location of bone metastasis. The finite element method is useful for predicting fracture in individual patients with bone metastasis. Less

建立了骨质疏松症骨折风险评估的有限元模拟分析方法，并尝试通过高分辨率显微CT准确显示松质骨小梁结构来评估骨质量。然而，其应用于癌症患者是困难的，因为它需要在大面积上成像。裂缝的评价应以力学分析为基础，三维分析也是必要的。本研究的目的是建立一种实用的方法来分析骨转移瘤，由于骨转移瘤的性质不同，目前还没有建立骨折评估的分析方法。研究对象是4例不同类型的骨转移瘤患者，放疗后可以通过CT进行随访，但病情没有明显进展。从临床CT图像中制备骨的有限元模型，并使用能够集成图像处理的软件MECHANICAL FINDER OPTIS进行分析。 ...更多信息 和力学分析。从获得的图像中提取椎骨区域。准备外形数据，将基本网格尺寸设置为2mm，并自动生成实体四面体单元。关于分析条件，椎体的底面被完全约束，承重区域均匀地设置在椎体的上表面上，并且重量在轴向方向上垂直加载。弹性分析加载600N，非线性骨折线预测分析加载1000N，骨转移瘤的分析均未发现可预测的结果，溶骨性骨转移瘤的分析可预测骨折的发生。预测区域不一定靠近骨转移灶，提示骨转移灶的形状和位置的影响。有限元方法对于预测骨转移患者的骨折非常有用。少