Integrated research on coronary plaque imaging for the establishment of preventive radiology.

冠状动脉斑块成像的综合研究以建立预防放射学。

• 批准号: 15209039
• 负责人: NISHIMURA Tsunehiko
• 金额: $ 20.55万
• 依托单位: Graduate School of Medical Science, Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15209039/
• 关键词: Preventive Radiology; Coronary plaque; Multi slice CT; MR; Molecular Imaging; Fusion image; 冠動脈硬化イメージング; 不安定プラーク; 動脈硬化巣; FDG-PET; 放射線予防医学; 高速MRI技術; ^<99m>Tc-Annexin

There are few researches of preventive radiology on coronary sclerotic imaging, since many researches have been focused on ischemic heart disease until now. Recently, higher advance of multi-slice CT and MRI has made visualization of coronary arterial involvement including sclerosis and plaque. Furthermore, PET and SPECT has made active plaque deposition as molecular imaging. Our research has focused on integrated approach of coronary animal and human plaque imaging by CT/MR(anatomy) and PET/SPECT(function). In conclusion, coronary plaque imaging has been established by our integrated research. Furthermore, early detection of coronary sclerosis before ischemic heart disease(coronary stenosis) has made early cholesterol lowering therapy and decrease of medical fee and promotion of QOL.

由于目前的研究主要集中在缺血性心脏病上，冠状动脉造影的预防性放射学研究较少。近年来，随着多层螺旋CT和MRI技术的发展，冠状动脉病变（包括硬化和斑块）的显示已成为可能。此外，PET和SPECT作为分子成像使斑块沉积活跃。我们的研究重点是通过CT/MR（解剖学）和PET/SPECT（功能）对冠状动脉动物和人体斑块成像的集成方法。综上所述，通过我们的综合研究，冠状动脉斑块成像已经建立。此外，在缺血性心脏病（冠状动脉狭窄）发生前，早期发现冠状动脉硬化，可使患者尽早接受降胆固醇治疗，从而降低医疗费用，提高生活质量。

项目成果

Imaging of lesions in a murine rheumatoid arthritis model with a humanized anti-interleukin-6 receptor antibody.

使用人源化抗白细胞介素 6 受体抗体对小鼠类风湿性关节炎模型中的病变进行成像。

• 发表时间: 2005
• 期刊: Ann Nucl Med 19
• 作者: Sugimoto K;Nishimoto N;Yoshizaki K;Nishimura T 他1名.
• 通讯作者: Nishimura T 他1名.

Myocardial scintigraphy using a fatty acid analogue detects coronary artery disease in hemodialysis patients.

使用脂肪酸类似物的心肌闪烁扫描可检测血液透析患者的冠状动脉疾病。

• 发表时间: 2004
• 期刊: Kidney Int 66
• 作者: Nishimura M;Hashimoto T;Nishimura T;Ono T 他6名.
• 通讯作者: Ono T 他6名.

Pitfalls of FDG-PET for the diagnosis of osteoblastic bone metastases in patients with breast cancer

• DOI: 10.1007/s00259-005-1842-8
• 发表时间: 2005-11-01
• 期刊: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
• 影响因子: 9.1
• 作者: Nakai, T;Okuyama, C;Nishimura, T
• 通讯作者: Nishimura, T

Inter-institution preference-based variability of ejection fraction and volumes using quantitative gated SPECT with 99mTc-tetrofosmin:: a multicentre study involving 106 hospitals

• DOI: 10.1007/s00259-005-1916-7
• 发表时间: 2006-02-01
• 期刊: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
• 影响因子: 9.1
• 作者: Nakajima, K;Nishimura, T
• 通讯作者: Nishimura, T

99mTc-Hynic-annexin V imaging to evaluate inflammation and apoptosis in rats with autoimmune myocarditis

• DOI: 10.1007/s00259-002-1006-z
• 发表时间: 2003-02-01
• 期刊: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
• 影响因子: 9.1
• 作者: Tokita, N;Hasegawa, S;Nishimura, T
• 通讯作者: Nishimura, T