Assessment of pathopysiologic diagnosis and quantitative evaluation of therapeutic effect in cardiac failure by using myocardial metabolic and receptor imaging.

利用心肌代谢和受体成像评估心力衰竭的病理生理学诊断和治疗效果的定量评估。

• 批准号: 07407026
• 负责人: NISHIMURA Tsunehiko
• 金额: $ 16.26万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07407026/
• 关键词: Metabolism; Receptor; SPECT; PET; Hypertrophic cardiomyopathy; Dilated cardiomyopathy; beta-blocker

Assessment of pathophysiologic diagnosis and quantitative evaluation of therapeutic effect in cardiac . failure has been investigated by using myocardial metabolic and receptor imaging from 1995 to 1998. The following researches were done from the basic and clinical points.1. basic research using isolated perfused rat heart and autoradiographyMetabolism of ^<123>I-BMIPP was clarified by isolated perfused rat heart model. Glucose uptake in stunned myocardium was also clarified by ^<31>P-MR spectroscopy and it was confirmed to be caused by the translocation of glucose transporter. Tracer kinetics of ^<99M>Tc-nitroimidazole was also clarified. These tracers were applied to animal models such as DCM hamster (Bio l4_<beta>6) etc. It was conformed that the metabolic and receptor changes were preceded before the flow and functional changes by autoradiography.2. clinical research using SPECT and PET^<123>I-BMiPP myocardial SPECT was useful for the assessment of severity of hypertrophic cardiomyopathy (HCMz) and therapeutic effect of Coenzyme Q1O in dilated cardiomyopathy (DCM). ^<123>I-MIBG was useful for the severity and therapeutic effect of BETA-blocker in DCM.Furthermore, ^<18>F-FDG myocardial PET was extremely useful for the pathophysiologic diagnosis of HCM and DCM.These findings should be necessary for the indication of heart transportation.

心脏病理生理诊断评价及疗效量化评价。从1995年到1998年，使用心肌代谢和受体成像对失败进行了调查。从基础和临床两个角度进行了以下研究。大鼠心脏离体灌流法基础研究及放射自显影研究用大鼠离体心灌流模型阐明I-BMIPP的代谢。顿抑心肌的葡萄糖摄取也被核磁共振波谱证实为葡萄糖转运蛋白易位所致。并阐明了~(99)M&GT；~(99)Tc-硝基咪唑的示踪动力学。这些示踪剂被应用于DCM仓鼠(Bio L4&lt；beta&Gt；6)等动物模型，通过放射自显影证实代谢和受体的变化先于血流和功能的变化。应用SPECT和PET、123&GT；I-BMIPP心肌SPECT进行的临床研究有助于评价肥厚型心肌病(HCMz)的严重程度和辅酶Q1O治疗扩张型心肌病(DCM)的疗效。I-MIBG有助于判断β-受体阻滞剂对肥厚性心肌病的严重程度和治疗效果。此外，18F-FDG心肌PET对肥厚性心肌病和糖尿病心肌病的病理生理诊断非常有用，这些发现对心脏运输的指征是必要的。

项目成果

K.Hashimoto et al.: "Enhancement of glucose uptake in stunned myocardium : Role of glucose transporter." Am J Physiol. H1122-H1130 (1997)

K.Hashimoto 等人：“顿顿心肌中葡萄糖摄取的增强：葡萄糖转运蛋白的作用。”

Y.Watanabe et al.: "Contribution of hypoxia to the development of cardiomyopathy in hamsters." Cardiovasc Res. 35. 217-222 (1997)

Y.Watanabe 等人：“缺氧对仓鼠心肌病的影响。”

Y.Hirose et al.: "Viable but denervated right ventricular myocardium : A case of eisenmenger reaction." Cardiology. 88. 609-612 (1997)

Y.Hirose 等人：“存活但去神经支配的右心室心肌：艾森曼格反应的一个案例。”

T.Uehara et al: "Myocardial glucose metabolism in patients with hypertrophic cardiomyopathy:Assessment by F-18-FDG PET study" Annals of Nuclear Medicine. 12. 95-103 (1998)

T.Uehara 等人：“肥厚型心肌病患者的心肌葡萄糖代谢：通过 F-18-FDG PET 研究进行评估”《核医学年鉴》。

S.Hasegawa et al.: "Glucose tolerance and myocardial F-18 fluorodeoxyglucose uptake in normal regions in coronary heat disease patients." Ann Nucl Med. 6. 363-368 (1998)

S.Hasekawa 等人：“冠心病患者正常区域的葡萄糖耐量和心肌 F-18 氟脱氧葡萄糖摄取。”