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宇宙長期滞在模擬の生理的変化を人工重力の遠心負荷で予防出来るか

人造重力的离心载荷能否阻止长期停留在太空所模拟的生理变化？

基本信息

批准号：
07407013
负责人：
YAJIMA Kazuyoshi
金额：
$ 12.16万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07407013/
关键词：
6 degrees head down tilt stop hematocrit increase short arm human centrifuge artificial gravity long term space flight cardiovascular countermeasure space medicine research 地上での無重量模擬宇宙循環系変化の対策人工重力 6度ヘッドダウン(HDT)2G1時間の遠心負荷短腕遠心機 /

项目摘要

4 days 6 degrees head down tilt bed rest (HDT) experiments were conducted for 10 healthy male students at Nihon University School of Medicine. By a courtesy of Shimizu Co., a 1.8 m radius human centrifuge was set at their Space Development Laboratory and the above mentioned HDT facilitiy was atatched next to the centrifuge room. 10 subjects were kept under a severe control to keep the HDT 24 hours except 15 minutes of secretion and one hour of 2Gz+ centrifugation every day. From many HDT studies up to the present, it has been clear that only hematocrit significantly increases among many physiological changes according to 4 days HDT.No significant increase was observed among the averaged hematocrit values during the 4 days HDT.By other countermeasures as walking arround or standind on the bed (lG load simulation) for up to 2 hours in 4 days HDT, conducted by Convertino et al., hematocrit increase could not be intercepted. This report is the first deta of short arm centrifuge, proving that the centrifugation is more effective than other countermeasures to inhibit the hematocrit increase normally induced in 4 days HDT on the ground. Considering these facts, centrifugation is the first choice to be adopted for artificial gravity in a long term space life, compared with the other countermeasures such as some exercises or other conventional ways to prevent the physiological changes due to the microgravity condition in space.

在日本大学医学部对10名健康男性学生进行了为期4天的6度头低位倾斜卧床（HDT）实验。由清水公司提供，在他们的空间发展实验室设置了一个半径为1.8米的人体离心机，上述HDT设施就安装在离心机室旁边。10名受试者每天严格控制HDT 24小时，但不进行15分钟的分泌和1小时的2Gz+离心。从迄今为止的许多HDT研究来看，已经清楚的是，在根据4天HDT的许多生理变化中，只有红细胞比容显著增加。在4天HDT期间，在平均红细胞比容值中没有观察到显著增加。通过Convertino等人进行的其他对策，如在4天HDT中走动或在床上站立（lG负荷模拟）长达2小时，血细胞比容增加不能被拦截。本文首次报道了短臂离心机的使用情况，证明了短臂离心机比其它措施更能有效地抑制地面HDT 4天引起的红细胞压积升高。考虑到这些事实，与其他措施如一些练习或其他常规方法相比，离心是长期空间生活中人工重力的首选，以防止由于空间微重力条件引起的生理变化。