Collabolative Study on Space Adaptation and Countermeasures

空间适应及对策协作研究

• 批准号: 10044323
• 负责人: YAJIMA Kazuyoshi
• 金额: $ 3.39万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10044323/
• 关键词: cardiovascular countermeasure; 6 degrees head down tilt; space medicine; long-term weightlessness exposure; human short-arm centrifuge; artificial gravity; countermeasure for bone mineral loss in space; 長期微小重量環境暴露; 6度ヘッドダウン臥床; 宇宙医学の対策; 微小重力場の長期生

Attended scientific meeting were : Aerospace Medical Association (AsMA) (1998.5, Seatle), International Academy of Astronautics (IAA)/Internationa Astronautical Federation (IAF) (1998.9, Melbourne), Purdue University Biomedical Engineering Center (1998. 10, West Lafayette, Indiana), Artificial Gravity Workshop (1999.1, Houston), IAA (1999.3, Paris), The Royal Aeronautical Society's lecture (1999.3, London), AsMA (1999.5, Detroit), IAA/IAF (1999.10, Amsterdam), and IAA (2000.3, Paris).Now our study results are properly estimated by many researchers in the world that every day +2Gz-60 minutes centrifugation stopped the hematocrit increase from the subjects of 4 days head down tilt bed rest. That shows this kind of centrifuge can be used in future International Space Station (ISS) for a powerful countermeasure to prevent the cardiovascular deconditioning as well as bone minaral loss and other medical risks due to a long time exposure of weightlessness.A collaborating experiment of 14 days 6 degrees head down tilt bed rest with Nagoya University Institue of Environemental Medicine has been continued since 1998, and this year we measured newly bone markaers from the subject's serum and urine. Osteogenesis marker showed no significant changes, while bone resorption marker increased significantly after 14 days of head down bed rest. The results are reasonably corresponding to those in space.We continue our research activity on human short-arm centrifuge for future ISS use, collaborating with NASA life science people, Dr. Nicogossian and Dr. Vernikos as well.

参加的科学会议有：航空航天医学协会（AsMA）（1998.5，西雅图），国际宇航科学院（IAA）/国际宇航联合会（IAF）（1998.9，墨尔本），普渡大学生物医学工程中心（1998.10，西拉斐特，印第安纳），人工重力研讨会（1999.1，休斯顿），IAA（1999.3， 巴黎）、皇家航空学会的讲座（1999.3，伦敦）、AsMA（1999.5，底特律）、IAA/IAF（1999.10，阿姆斯特丹）和IAA（2000.3，巴黎）。现在我们的研究结果被世界上许多研究人员正确估计，每天+2Gz-60分钟离心停止了4天头低位的受试者的血细胞比容增加 卧床休息。这表明这种离心机可以在未来的国际空间站（ISS）中作为预防长期失重引起的心血管功能失调以及骨矿物质丢失等医疗风险的有力对策。自1998年起与名古屋大学环境医学研究所持续进行14天6度低头倾斜卧床休息实验，今年我们测量了新的骨标志物。 受试者的血清和尿液。低头卧床休息14天后，成骨标志物无明显变化，而骨吸收标志物明显增加。结果与太空中的结果相当一致。我们继续与 NASA 生命科学人员 Nicogossian 博士和 Vernikos 博士合作，进行人类短臂离心机的研究活动，以供未来国际空间站使用。

项目成果

Sasaki,T.,Yajima,K.,et al.: "Usefulness of Short-radius Human Centrifuge as a Countermeasure against Cardiovascular Deconditioning Simulated Weightlessness"Proceeding of the 21^<st> ISTS. 2. 1727-1732 (1998)

Sasaki,T.,Yajima,K.,et al.：“短半径人体离心机作为对抗心血管失调模拟失重的对策的有用性”第 21 届 ISTS 会议记录。

矢島一嘉: "宇宙における安全"信学技報. sss99-8. 7-11 (1999)

Kazuyoshi Yajima：“太空安全”IEICE 技术报告 sss99-8 (1999)。

Sasaki, T., Yajima, K., et al.: "Usefulness of Short-radius Human Centrifuge as a Countermeasure against Cardiovascular Deconditioning Simulated Weightlessness"Proceeding of the 21^<ST> ISTS. 2. 1727-1732 (1998)

Sasaki, T.、Yajima, K. 等人：“短半径人体离心机作为对抗心血管失调模拟失重的对策的有用性”21^<ST> ISTS 会议记录。

Rachel Armstrong: "Space Architecture"John Wiley & Sons Ltd.. (2000)

雷切尔·阿姆斯特朗：《太空建筑》约翰·威利

矢島一嘉: "宇宙医学"第25回日本医学会総会会誌. 3. 41 (1999)

矢岛一义：《宇宙医学》日本医学会第25届总会会刊3. 41（1999）。