Collabolative Study on Space Adaptation and Countermeasures

参加科学会议的有：航空航天医学协会（1998.5，西雅图）、国际宇航科学院(IAA)/国际宇航联合会（IAF）（1998.9，墨尔本）、普渡大学生物医学工程中心（1998年）。10，西拉斐特，印第安纳州)，人工重力研讨会（1999.1，休斯顿），IAA（1999.3，巴黎），皇家航空学会的讲座（1999.3，伦敦），AsMA（1999.5，底特律），IAA/IAF（1999.10，阿姆斯特丹），IAA（2000.3，巴黎）。现在我们的研究结果被国际上许多研究者正确估计，每天+2Gz-60分钟的离心使受试者头向下倾斜卧床休息4天的红细胞压积增加停止。这表明，这种离心机可以用于未来的国际空间站（ISS），为防止长期暴露在失重状态下导致的心血管疾病和骨矿物质流失等医疗风险提供有力的对策。自1998年以来，我们与名古屋大学环境医学研究所合作进行了为期14天的6度头向下倾斜卧床休息实验，今年我们从受试者的血清和尿液中测量了新的骨标志物。成骨指标无明显变化，而骨吸收指标在头朝下卧床14天后明显升高。所得结果与空间观测结果基本吻合。我们继续我们的人类短臂离心机的研究活动，为未来的国际空间站使用，与美国国家航空航天局的生命科学人员，博士nico流言和博士Vernikos以及合作。

Attended scientific meeting were : Aerospace Medical Association (AsMA) (1998.5, Seatle), International Academy of Astronautics (IAA)/Internationa Astronautical Federation (IAF) (1998.9, Melbourne), Purdue University Biomedical Engineering Center (1998. 10, West Lafayette, Indiana), Artificial Gravity Workshop (1999.1, Houston), IAA (1999.3, Paris), The Royal Aeronautical Society's lecture (1999.3, London), AsMA (1999.5, Detroit), IAA/IAF (1999.10, Amsterdam), and IAA (2000.3, Paris).Now our study results are properly estimated by many researchers in the world that every day +2Gz-60 minutes centrifugation stopped the hematocrit increase from the subjects of 4 days head down tilt bed rest. That shows this kind of centrifuge can be used in future International Space Station (ISS) for a powerful countermeasure to prevent the cardiovascular deconditioning as well as bone minaral loss and other medical risks due to a long time exposure of weightlessness.A collaborating experiment of 14 days 6 degrees head down tilt bed rest with Nagoya University Institue of Environemental Medicine has been continued since 1998, and this year we measured newly bone markaers from the subject's serum and urine. Osteogenesis marker showed no significant changes, while bone resorption marker increased significantly after 14 days of head down bed rest. The results are reasonably corresponding to those in space.We continue our research activity on human short-arm centrifuge for future ISS use, collaborating with NASA life science people, Dr. Nicogossian and Dr. Vernikos as well.