Collabolative Study on Space Adaptation and Countermeasures

出席科学会议的有：航天医学协会(ASMA)(1998.5，西雅图)、国际宇航科学院(宇航科学院)/国际宇航联合会(宇航联合会)(1998.9，墨尔本)、普渡大学生物医学工程中心(1998.9，墨尔本)。10，西拉斐特，印第安纳州)，人工重力研讨会(1999.1，休斯顿)，IAA(1999.3，巴黎)，皇家航空学会的讲座(1999.3，伦敦)，ASMA(1999.5，底特律)，IAA/IAF(1999.10，阿姆斯特丹)和IAA(2000.3，巴黎)。现在我们的研究结果被世界上许多研究人员正确地估计，每天+2GZ-60分钟的离心机阻止了4天头朝下倾斜床休息的受试者的红细胞压积增加。这表明这种离心机可以用于未来的国际空间站(ISS)，作为一种强有力的对策，防止因长期暴露于失重而导致的心血管疾病和骨矿物质丢失等医疗风险。自1998年以来，与名古屋大学环境医学研究所进行了14天6度头低位倾斜卧床休息的合作实验，今年我们从受试者的血清和尿液中测量了新的骨标记物。头低位卧床14d后，成骨指标无明显变化，骨吸收指标明显升高。结果与太空中的结果相当吻合。我们继续开展人类短臂离心机的研究活动，以供未来国际空间站使用，并与NASA生命科学人员、尼戈斯安博士和韦尔尼科斯博士合作。

Attended scientific meeting were : Aerospace Medical Association (AsMA) (1998.5, Seatle), International Academy of Astronautics (IAA)/Internationa Astronautical Federation (IAF) (1998.9, Melbourne), Purdue University Biomedical Engineering Center (1998. 10, West Lafayette, Indiana), Artificial Gravity Workshop (1999.1, Houston), IAA (1999.3, Paris), The Royal Aeronautical Society's lecture (1999.3, London), AsMA (1999.5, Detroit), IAA/IAF (1999.10, Amsterdam), and IAA (2000.3, Paris).Now our study results are properly estimated by many researchers in the world that every day +2Gz-60 minutes centrifugation stopped the hematocrit increase from the subjects of 4 days head down tilt bed rest. That shows this kind of centrifuge can be used in future International Space Station (ISS) for a powerful countermeasure to prevent the cardiovascular deconditioning as well as bone minaral loss and other medical risks due to a long time exposure of weightlessness.A collaborating experiment of 14 days 6 degrees head down tilt bed rest with Nagoya University Institue of Environemental Medicine has been continued since 1998, and this year we measured newly bone markaers from the subject's serum and urine. Osteogenesis marker showed no significant changes, while bone resorption marker increased significantly after 14 days of head down bed rest. The results are reasonably corresponding to those in space.We continue our research activity on human short-arm centrifuge for future ISS use, collaborating with NASA life science people, Dr. Nicogossian and Dr. Vernikos as well.