Some factors modifying airway defensive reflexes

改变气道防御反射的一些因素

基本信息

批准号：
07457349
负责人：
NISHINO Takashi
金额：
$ 2.43万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457349/
关键词：
Airway defensive reflexes Propofol Fentanyl Sevoflurane 気道反射気道粘膜麻酔深度

项目摘要

The first purpose of this study is to elucidate patterns of airway defensive reflexes elicited by a constant stimulation of airway mucosa in humans and the second purpose is to see the importance of various factors influencing airway reflexes in modification of airway defensive reflex responses. In this study we established the methidoiogy of elicitation and eveluation of airway defensive reflexes in humans. We also investigated the effects of an intravenous anesthetic agent (propofol) and a narcotic (fentanyl) on airway defensive reflexes. In addition, the effects of smoking habit and the influence of a voltile agent (sevoflurane) on airway defensive reflexes were investigated. The results were summarized as follows :1.Both laryngeal and tracheal stimulation caused protective responses, such as cough reflex, expiration reflex, and spasmodic panting whereas bronchial stimulation caused little or no such responses.2.An increase in depth of anesthesia shortened the response duration but did not affect the nature of the elicited responses.3.It was impossible to suppress the airway defensive reflexes by administration of propofol alone but an addition of a small amount of fentanyl effectively depressed the airway defensive reflexes.4.Smoking habit augmented the airway reflex responses but this was evident only with mechanical stimulation of the airway mucosa.5.Sevoflurane which possesses a very mild airway-irritation may elicit airway defensive responses through the stimulation of the nasal mucosa.

这项研究的第一个目的是阐明通过人类中气道粘膜持续刺激引起的气道防御反射模式，第二个目的是查看影响气道反射在修改气道防御反射反应中的各种因素的重要性。在这项研究中，我们建立了人类气道防御反射的诱导和逃避的甲基化学。我们还研究了静脉麻醉剂（丙泊酚）和麻醉（芬太尼）对气道防御反射的影响。此外，还研究了吸烟习惯和电压剂（七氟烷）对气道防御反射的影响。结果总结如下：1。喉刺激和气管刺激会导致保护性反应，例如咳嗽反射，过期反射和痉挛性喘息，而支气管刺激几乎没有或没有这种反应引起的反应。。仅丙泊酚，但增加了少量芬太尼有效地抑制了气道防御反射。4。漫长的习惯增强了气道反射反应的反应，但这仅在机械刺激气道粘膜的机械刺激下才能显而易见。Sevoflurane。柔和的气道通过非常温和的气道防御性反应，可以通过刺激性反应来刺激刺激刺激。