Immunological analysis of osteopenea during pregnancy and puerperium

在怀孕期间，高雌激素水平被认为是保护母亲的骨骼和骨吸收被禁止。分娩后，低雌激素和高催乳素被认为能诱导骨吸收。然而，我们对骨代谢标志物和骨矿物质密度的分析表明，在怀孕期间骨吸收增加，在产褥期骨形成增加。未妊娠期外周单核细胞释放的细胞因子IL-1、IL-6、tnf - α激活破骨细胞功能，诱导骨吸收。我们分析了外周单核细胞产生的细胞因子，发现在妊娠期雌激素水平高的情况下，细胞因子大量产生。这与目前雌激素在骨代谢中的教条相比是自相矛盾的现象。我们必须阐明怀孕期间这种自相矛盾的免疫现象。

During pregnancy, high estrogen levels had thought to protect the maternal bone and bone resorption to be prohibited. and after delivery, low estrogen and high prolactin had thought to induce bone resorption. Our analysis of bone metabolic marker and bone mineral density, however, disclosed that bone resorption is increased during pregnancy and in the puerperium bone formation is increased. During no pregnancy, cytokines released by peripheral mononuclear cells, IL-1, IL-6 and TNF-alpha, activate the osteoclast function and induce the bone resorption. We analyzed the production of cytokines from the peripheral mononuclear cells and found that, in high estrogen levels in pregnancy, much amount of cytokines were produced. This is paradoxical phenomenon compared with nowadays estrogen dogma in bone metabolism. We must elucidate this paradoxical immune phenomenon during pregnancy.