Immunological analysis of osteopenea during pregnancy and puerperium

孕产期骨质疏松的免疫学分析

• 批准号: 07457382
• 负责人: FUKUOKA Hideoki
• 金额: $ 4.99万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457382/
• 关键词: cytokine; osteoclast bone; metabolic marker; pregnancy; puerperium; 妊娠性骨粗鬆症; 末梢血単球

During pregnancy, high estrogen levels had thought to protect the maternal bone and bone resorption to be prohibited. and after delivery, low estrogen and high prolactin had thought to induce bone resorption. Our analysis of bone metabolic marker and bone mineral density, however, disclosed that bone resorption is increased during pregnancy and in the puerperium bone formation is increased. During no pregnancy, cytokines released by peripheral mononuclear cells, IL-1, IL-6 and TNF-alpha, activate the osteoclast function and induce the bone resorption. We analyzed the production of cytokines from the peripheral mononuclear cells and found that, in high estrogen levels in pregnancy, much amount of cytokines were produced. This is paradoxical phenomenon compared with nowadays estrogen dogma in bone metabolism. We must elucidate this paradoxical immune phenomenon during pregnancy.

怀孕期间，高雌激素水平曾被认为可以保护母体骨骼并禁止骨吸收。分娩后，低雌激素和高催乳素被认为会诱导骨吸收。然而，我们对骨代谢标志物和骨矿物质密度的分析表明，怀孕期间骨吸收增加，产褥期骨形成增加。非妊娠期间，外周单核细胞释放的细胞因子IL-1、IL-6和TNF-α激活破骨细胞功能并诱导骨吸收。我们分析了外周单核细胞产生的细胞因子，发现妊娠期雌激素水平较高时，会产生大量细胞因子。与当今骨代谢中的雌激素教条相比，这是一个矛盾的现象。我们必须阐明怀孕期间这种矛盾的免疫现象。

项目成果

Fukuoka, H., E.Kasahara, Y.Seino, S.Nishiyama, T.Hirota: "Bone metabolism and health care in childhood" Health Science. 36. 612-617 (1996)

Fukuoka, H.、E.Kasahara、Y.Seino、S.Nishiyama、T.Hirota：“儿童时期的骨代谢与保健”健康科学。

Haruna M., H.Fukuoka: "Metabolic turnover of bone during pregnancy and puerperium" 89. 112-132 (1996)

Haruna M., H.Fukuoka：“怀孕和产褥期骨的代谢更新”89. 112-132 (1996)

福岡秀興.: "母子の健康とカルシウム" 女性のためのこつこつ講座. 2. 6-9 (1995)

Hideoki Fukuoka.：“母婴健康与钙”女性提示和技巧课程。2. 6-9 (1995)。

Ishizaki Y, Fukuoka H, Ishizaki T: "An Investigation of psychological stress due to bed rest." Acta Physiol Scand. (in press).

Ishizaki Y、Fukuoka H、Ishizaki T：“卧床休息造成的心理压力的调查”。

福岡秀興 他: "糖蛋白ホルモン分子多様性解析への1つの手技" 比較内分泌学会ニュースレター. 54. 27-36 (1996)

Hideoki Fukuoka 等人：“一种分析糖蛋白激素分子多样性的技术”比较内分泌学会通讯 54. 27-36 (1996)。