Establishment of the Standard for Radiotherapy on Abnormality of the Suppresser Oncogene p53

抑癌基因p53异常放疗标准的建立

• 批准号: 07557367
• 负责人: FURUKAWA Souhei
• 金额: $ 0.45万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557367/
• 关键词: Radiation Therapy; Oncogene p53; head and neck cancer

Radiotherapy is an appropriate treatment modality for head and neck cancer, because it seldom is accompanied by functional and aesthetical problem. But in some cases, radiation is not effective. Decision-making is based on analysis of prognostic markers. However, the known factors have a relatively low predictive value.p53 is a tumor suppresser gene and its mutation are considered to be a critical in the development of human malignancies. Since p53 is required for radiation induced apoptosis, analysis of p53 status may be a useful prognostic determinant for head and neck cancer. We analyzed p53 status of patients who were treated at the Department of Oral Radiology, Dental School.Our goal for this study was to determine whether different p53 status had different prognostic implication.1.Forty-five cases with head and neck cancer were made analysis of p53-oncogene abnormalities by PCR-SSCP method, resulting 18 of 45 (40%) cases gave a positive result.2.The efficacy of radiotherapy was evaluated with statistical method. The local control rate and the changes or the tumor sizes were estimated with clinical follow-up data and significance was tested by means of X^2. The probability of survival was estimated with Kaplan-Maier method and significance was tested by generalized Wilcoxon test.3.By multivariate analysis, there were no statistically significant correlation between p53-abnormal cases (positive group) and p53-normal cases (negative group).

放射治疗是头颈癌的一种合适的治疗方式，因为它很少伴有功能和美观问题。但在某些情况下，放射治疗并不有效。决策是基于对预后标志物的分析。然而，已知的因素预测价值相对较低。P53是一种肿瘤抑制基因，其突变被认为在人类恶性肿瘤的发生发展中起关键作用。由于P53是辐射诱导细胞凋亡所必需的，对P53状态的分析可能是头颈癌有用的预后决定因素。我们分析了口腔医学院口腔放射科就诊患者的P53基因表达情况，目的是探讨不同P53基因表达状态是否具有不同的预后意义。1.采用聚合酶链式反应-单链构象多态方法对45例头颈癌患者的P53癌基因异常进行分析，结果阳性18例(40%)。生存概率采用Kaplan-Maier法，生存概率采用广义Wilcoxon检验。3多因素分析显示，P53异常组(阳性组)与P53正常组(阴性组)之间无统计学意义。

项目成果

古川惣平: "唾液腺悪性腫瘍の治療、唾液腺悪性腫瘍の放射線治療" 歯科ジャーナル. 41. 109-114 (1995)

Sohei Furukawa：“唾液腺恶性肿瘤的治疗，唾液腺恶性肿瘤的放射治疗”《牙科杂志》41. 109-114（1995）。