Research on establish of standard for injurious effects after radiation therapy of cancer in head and neck

头颈部肿瘤放射治疗后损伤标准制定的研究

• 批准号: 06671880
• 负责人: FURUKAWA Souhei
• 金额: $ 1.34万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671880/
• 关键词: Injurious Effects; 後障害; 頭頸部癌; 頭頚部癌

It is well known that hyposalivation caused by irradiation of salivary glands in humans results in a dramatic increase in the incidence of dental caries. The purpose of the present study is to examine the effects of irradiation-induced hyposalivation on the dental caries in SPF rats infected with mutans streptococci.SPF Sprague-Dawley rats infected with S.mutans MT8148R and given caries-inducing diet 2000 received irradiation under pentobarbital anesthesia on a neck region including parotid, submandibular and sublingual glands. Hyposalivation was induced by 20Gy of irradiation and enhancement of caries incidence was recognized in rats receiving 35Gy. 5OGY of radiation administered by fractionated irradiation method, induced heavy accumulation of dental plaque and severe dental caries. There was a statistically significant correlation between caries scores and flow rates of saliva in hyposalivated rats.SPF SD rats, infected with S.mutans MT8148R and fed diet 2000, were either completely … More or partially surgically hyposalivated. Complete removal of the major salivary glands led to the greatest increase in the caries incidence. Partial removal of either the parotid or submandibular and sublingual glands reduced the flow rate of whole saliva and enhanced the caries incidence. A significant correlation was also observed between caries score and flow rate of whole saliva in partially hyposalivated rats. However, the recovery of inoculated streptococci from hyposalivated rats was not always high. SPF SD rats, fed diet 2000, and receiving surgery for complete hyposalivation without inoculation of mutans streptococci manifested severe dental caries, while sham-operated rats were caries free.Bacteriological examination demonstrated that the total number of lactobacilli increased significantly, while total cultivatable microorganisms and total streptococci stayd relatively constant. These results indicated that saliva flow exerts a significant influence in dental caries incidence and microorganisms other than mutans streptococci may play some role in promoting dental caries in hyposalivated rats.16FA01 : Radiation Therapy Less

众所周知，照射人类唾液腺引起的唾液分泌减少导致龋齿发病率急剧增加。本研究的目的是检查照射诱导的少涎对感染变形链球菌的SPF大鼠龋齿的影响。SPF Sprague-Dawley大鼠感染变形链球菌MT 8148 R并给予致龋饮食2000，在戊巴比妥麻醉下接受颈部区域包括腮腺、下颌下和舌下腺的照射。20 Gy照射可引起大鼠唾液分泌减少，35 Gy照射可引起大鼠龋病发生率增加。采用分次照射方法进行50 Gy的辐射，导致牙菌斑大量堆积和严重龋齿。低唾液酸大鼠龋损评分与唾液流率之间存在显著相关性，感染变形链球菌MT 8148 R的SPF级SD大鼠在进食2000饲料后， ...更多信息 或者部分唾液分泌不足完全切除大唾液腺导致龋齿发病率的最大增加。部分切除腮腺或颌下腺和舌下腺均会降低全唾液的流速，并增加龋齿的发生率。部分唾液不足大鼠的龋齿评分与全唾液流速之间也存在显着相关性。然而，从低唾液大鼠中接种链球菌的回收率并不总是很高。SPF级SD大鼠，喂饲2000份饲料，手术完全减唾液，不接种变形链球菌，实验组大鼠出现严重龋齿，假手术组大鼠无龋，细菌学检查显示乳酸杆菌总数明显增加，可培养微生物总数和链球菌总数相对稳定。这些结果表明，唾液流量对龋齿的发生率有显著影响，而变形链球菌以外的微生物可能在促进低唾液大鼠龋齿中发挥一定作用。16 FA 01：放射治疗减

项目成果

S.Furukawa: "High-Dose Rate Interstitial Radiotherapy in Carcinoma of the Tongue" Proceedings of the 10th ICDMFR,(Seoul, Korea 1994). 301-306 (1994)

S.Furukawa：“舌癌的高剂量率间质放射治疗”第 10 届 ICDMFR 会议记录（韩国首尔，1994 年）。

H. Fuchihata: "The Effect of Irradiation-induced Hyposalivation on Dental Caries Induction in Rats Fed High or Low-Sucrose Diet" Oral Radiology. 10. 29-33 (1994)

H. Fuchihata：“辐照诱导的唾液分泌不足对高或低蔗糖饮食大鼠龋齿诱导的影响”口腔放射学。

H.Fuchihata: "The Effect of Irradiation-induced Hyposalivation on Dental Caries Induction in Rats Fed High or Low-Sucrose Diet" Oral Radiology. 10(2), 0158. 29(109)-33(113) (1994)

H.Fuchihata：“辐射诱导的唾液分泌不足对高或低蔗糖饮食大鼠龋齿诱导的影响”口腔放射学。

古川惣平・渕端 孟: "唾液腺悪性腫瘍の放射線治療" 歯科ジャーナル. 41. 109-114 (1995)

Sohei Furukawa 和Meng Fuchibata：“唾液腺恶性肿瘤的放射治疗”《牙科杂志》41. 109-114 (1995)。

H,Fuchihata: "Results of Combined External Irradiation and Chemotherapy of Bleomycin or Peplomycin for Squamous Cell Carcinomas of the Lower Gingiva" Int.Radia.Oncol.Biol.Phys.29(4). 705-709 (1994)

H，Fuchihata：“博来霉素或培洛霉素联合外部照射和化疗治疗下牙龈鳞状细胞癌的结果”Int.Radia.Oncol.Biol.Phys.29(4)。