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Temproal change of Xerostomia by radiation therapy for head and neck cancer : clinical and image evaluattion

头颈癌放射治疗导致口干症的时间变化：临床和影像评估

基本信息

批准号：
17591960
负责人：
FURUKAWA Souhei
金额：
$ 2.37万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591960/
关键词：
head and neck cancers radiation therapy xerostomia clinical evaluation image evaluation 悪性腫瘍唾液腺

项目摘要

The xerostomia is one of complications for the radiation therapy for the head and neck cancer. It is considered the xerostomia is the most important factor for the patient's qualiy of life after rediation therapy far head and neck cancers.The aims of this study were to grasp correctly and analyze the sideration pattern of xerostomia after radiation therapy for head and neck cancers. We estimated the patients with head and neck cancers treated by exernal beam radiation therapy using questionnaire survey and amount measurement of saliva before radiation therapy, at one month, at six month, and at 32 months after radiation therapy, respectively.The questionnaire: item was evaluated based on a patient's self report, by the Visual analog scale method, entered the questionnaire in the patient itself. When radiation dose evaluation created a dose distribution figure with curative program equipment, it enforced dose evaluation of major salivary gland and minor salivary gland. However, since major salivary gland and minor salivary gland were three dimensional shapes, they made the average dose of the whole volume of these organs. The amount measuring method of saliva performed measurement which used all the amount measurement of mouth saliva, and a mouth moisture meter. About image evaluation, it evaluated using CT value and the contrast enhancement ratio of major salivary glands and minor salivary gland area.By evaluating these temporal change of xerostomia by clinical salivary gland feature on CT imaging, we could examine the relation patient's QOL obtained by subjective xerostomia with objective examination data of xerostomia or image diagnosis for salivary glands. As a result, it was suggested that there was correlation between a patients's xerostomia contrast enhancement ratio on CP imaging of a major salivary gland.

口干症是头颈癌放射治疗的并发症之一。人们认为口干症是头颈部肿瘤放射治疗后影响患者生活质量的最重要因素。本研究的目的是正确把握和分析头颈部肿瘤放疗后口干症的考虑模式。我们分别在放射治疗前、放射治疗后1个月、6个月和32个月通过问卷调查和唾液量测量来评估接受外束放射治疗的头颈癌患者。问卷：项目根据患者自述进行评估，采用视觉模拟量表法，将问卷录入患者自身。放射剂量评价用治疗程序设备建立剂量分布图时，对大唾液腺和小唾液腺进行剂量评价。然而，由于大唾液腺和小唾液腺是三维的形状，他们得出了这些器官的整个体积的平均剂量。唾液量测量法采用全部口腔唾液量测量法和口腔水分计进行测量。在图像评价方面，采用CT值及大唾液腺和小唾液腺区域的对比增强比进行评价。通过临床涎腺的CT表现来评价口干症的时间变化，可以比较主观口干症患者的生活质量与客观口干症检查资料或涎腺影像学诊断的关系。因此，我们认为患者的口干增强率与大唾液腺CP成像之间存在相关性。