Preparation of Surface-Cationized Regenerated Cellulose Membrane and Investigation of their Properties

表面阳离子化再生纤维素膜的制备及其性能研究

• 批准号: 07558122
• 负责人: SUZUKI Kyoji
• 金额: $ 2.24万
• 依托单位: Shizuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07558122/
• 关键词: Cationization; Regenerated cellulose; Hemodialysis membrane; Complement activation; Dialyzer; 補体価; アミノ基

Cationization of regenerated cellulose membranes by Michael reaction using dimenthyl-aminopropylacrylamide (DMAPAA) and trimethylaminopropylacrylamide (TMAPAA) proceeded favorably at 35-55ﾟC.The rate of addition reaction of TMAPAA was higher than that of DMAPAA.0.80% mumol/cm^2 of TMAPAA was combined at 45ﾟC.Activation energy for Michael addition of TMAPAA was found to be 19kcal/mol, which was almost identical with that for DMAPAA (19kcal/mol). Contact angle of cationized membranes increased moderately with reaction time, while positive zeta-potentials could not be obtained. Favorable suppression of complement activation was observed from the C1150 measurement.Primary aminantion of regenerated cellulose membranes was carried out by Hofmann reaction of carbamoylehtylated membranes. Hofmann reaction readily proceeded, however, Tensile strength of the cationized membranes decreased with increasing the degree of polymerization. Cationization of the membrane of dialyzer also proceeded, however, yellowing of the membrane was observed in highly cationized dialyzers. Therefore, slightly cationized membrane was preferable for putting into practical use.

用二甲基氨丙基丙烯酰胺（DMAPAA）和三甲基氨丙基丙烯酰胺（TMAPAA）对再生纤维素膜进行Michael加成反应，在35-55 ℃进行，TMAPAA的加成反应速率高于DMAPAA，在45 ℃时，TMAPAA的结合量为0.80 μ mol/cm ^2，TMAPAA的Michael加成反应活化能为19 kcal/mol，与DMAPAA（19 kcal/mol）的结果基本一致。阳离子化膜的接触角随着反应时间的延长而增加，但不能获得正的zeta电位。通过C1150测定观察到对补体激活的有利抑制。再生纤维素膜通过氨甲酰乙基化膜的Hofmann反应进行初级胺化。Hofmann反应易于进行，但膜的拉伸强度随聚合度的增加而降低。透析器的膜也进行阳离子化，然而，在高度阳离子化的透析器中观察到膜变黄。因此，轻度阳离子化的膜更适合于实际应用。

项目成果

J.Zhang, E.Uchida, K.Suzuki, Y.Uyama and Y.Ikada: "Adhesive Interaction in Water between Surfaces with Various Zeta Ptentials" Journal of Colloid Interface Science. Vol.178. 371-373 (1996)

J.Zhang、E.Uchida、K.Suzuki、Y.Uyama 和 Y.Ikada：“具有各种 Zeta 电位的表面之间水中的粘附相互作用”胶体界面科学杂志。

Junfeng Zhang: "Adhesive Interaction in Water between Surfaces with Various Zeta Potentials" Jounal of Colloid and Interface Science. Vol.178. 371-373 (1996)

张俊峰：“具有不同Zeta电位的表面之间水中的粘附相互作用”胶体与界面科学杂志。

Junfeng Zhang: "Adhesive Interaction in Water between Surfaces with Various Zeta Potentials" Journal of Colloid and Interface Science. Vol.178. 371-373 (1996)

张俊峰：“具有各种 Zeta 电位的表面之间水中的粘附相互作用”胶体与界面科学杂志。