Survival Analysis and Prognosis for Children with Severe Motor and Intellectual Disabilities Syndrome (SMIDS)

严重运动和智力障碍综合征 (SMIDS) 儿童的生存分析和预后

• 批准号: 07670458
• 负责人: YOKOYAMA Eise
• 金额: $ 1.54万
• 依托单位: NIHON UNIVERSITY,SCHOOL OF MEDICINE,
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670458/
• 关键词: SMIDS; Survival Analysis; Prognosis; 重症心身障害児; 出生時体重

Purpose : In order to investigate factors affecting the prognosis for Children (patients) with Severe Motor and Intellectual Disabilities Synfrome"SMIDS", we calculated mortality and survival rate.Methods : We obtained a 14 year (from 1979 to 1993) survival rate for such patients cared at home from their health checkup data and fatal case reports by visiting nurse program in Tokyo.The number of the patients documented was 690 (alive 523, dead 167).The survival rate was calculated on these documented patients according to Kaplan-Meier's method and Cox's proportional hazard model was applied to the findings in order to analyze the factors affecting prognosis. The patient's grade of severity (Ooshima's Classification, Jittai Chousa Hyou Bunrui), posture, capabilities of locomotion, convulsion, way of feeding, weight at birth and etc.were selected from the SMID checklist items (by Nakamura) and survey data as variables for analysis.Results and Conclusion : The average death rate was 2.31% per year. The survival rate for the group with tube feeding was 43.8% (during 14 years)From the findings of proportional hazard model, it was suggested that prognosis depend significantly on the patient's way of feeding (tube feeding), which therefore deserves more attention and improvement.

目的：为探讨影响小儿脑梗死预后的因素，（例）严重运动和智力障碍综合征“SMIDS”，我们计算死亡率和生存率。我们获得了14年的（1979年至1993年）根据东京访问护士计划的健康检查数据和死亡病例报告，在家中护理的此类患者的存活率。记录的患者人数为690人生存523例，死亡167例，按Kaplan-Meier法计算生存率，应用考克斯比例风险模型分析影响预后的因素。从中村的SMID检查表项目和调查资料中选择患者的严重程度（大岛分类，Jittai Chousa Hyou Bunrui）、姿势、运动能力、惊厥、喂养方式、出生体重等作为变量进行分析。管饲组14年生存率为43.8%。根据比例风险模型分析，管饲方式对预后有重要影响，应引起重视和改进。