Children with Survival Analysis of Severe Motor and Intellectual Disabilities Syndrome

严重运动和智力障碍综合征儿童的生存分析

• 批准号: 11670390
• 负责人: YOKOYAMA Eise
• 金额: $ 1.86万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670390/
• 关键词: SMIDS; Survival Analysis; Prognosis

Children with Severe Motor and Intellectual Disabilities Syndrome(SMIDS) cared for in national hospitals were studied concerning their survival rate and prognosis. The 1988 nationalwide survey data on personal check lists for patients in national hospital. They had remained under observation for 8 years until 1955, when 6,005 were found to have survived and 515 died. Results were as follows ;1. Mortality rate was highest 14.9% for patients in Oshima's Category I.2. Survival analysis )by Kaplan-Meire methods) : Survival rate by age stood at 80.1 for children aged 0 to 9. The rate by sex amounted to 90.5% for males and 92.1% for females. The rate by posture was found to be 76.0% for those with unstable necks irrespective of posture. The rate by movement method was 79.7% for those who were unable to move to another place. The rate by convulsion frequency was estimated at 82.8% for those who had at least 10 seizers in the last 2 months. The rate by manual function stood at 73.8% for those whose hands remained clasped or immobile. The rate by mobility impaired was 86.0% for the bed-ridden. The rate by intelligence was relatively high, the lowest being 91% for those with an IQ of 20 or below. The rate by feeding method was estimated at 65.5% for those with tube feeding.3.The influence of those factors on prognosis was evaluated by means of Cox's proportional hazard model. Covariates found to be significantly correlative included : sex ; movement method ; feeding type ; morbidity impairment ; manual function ; age.

本研究以国立医院接受治疗的重度运动及智能障碍症候群儿童为研究对象，探讨其存活率及预后。1988年全国公立医院病人个人检查表调查资料。他们被观察了8年，直到1955年，发现6,005人存活，515人死亡。结果如下：1. Oshima分类I.2患者的死亡率最高，为14.9%。存活率分析（Kaplan-Meire法）：0至9岁儿童按年龄分列的存活率为80.1。按性别分列的比率为男性90.5%，女性92.1%。对于那些不稳定的颈部，无论姿势如何，姿势的发生率为76.0%。不能迁移者的迁移率为79.7%。对于在过去2个月内至少有10次惊厥的患者，惊厥频率估计为82.8%。对于那些手保持紧握或不动的人，手动功能的比率为73.8%。卧床者中，行动不便者占86.0%。按智商划分的比率较高，智商在20或以下的人最低，为91%。采用管饲法的患者中，喂养方式的发生率为65.5%。3.采用考克斯比例风险模型分析上述因素对预后的影响。发现显著相关的协变量包括：性别;运动方法;喂养类型;发病率受损;手功能;年龄。