DNA Typing of HLA Antigen in SIDS Autopsy Case

SIDS 尸检病例中 HLA 抗原的 DNA 分型

• 批准号: 07670503
• 负责人: HARA Masaaki
• 金额: $ 1.54万
• 依托单位: SAITAMA MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670503/
• 关键词: SIDS; HLA; DNA typing; HLA DQalpha; HLA DQB1; HLA DRB1; HLA DQα; HLA DQβ; HLA DRB; DNA抽出; HLA-DQα; HLA-DRB; HLAハプロタイプ

Sudden Infant Death Syndrome ( S I D S ) has been studied from a variety of perspectives, hawever, very little is known about its essential features and pathogenesis.Many reports have been published on the correlation between HLA antigens and various diseases, however, we have yet to find any reports which examined the relationship between SIDS and HLA antigens.Therefore, in the present study, we dtudied the relationship between SIDS and HLA antigen by obtaining blood samples from autopsies of SIDS cases conducted from 1995 through 1996, carrying out DNA typing of HLA DQ alpha, HLA DQBl and HLA DRB1, and then identifying HLA DQ・ DR antigen type.The following findings were Obtained.1. DNA typing of the genotypes was possible for all cases.2. The incidences of DQalpha1.2, DQB1**0602 and DRB1**15 (1501, -02) were high in SIDS.3. Acorrelation was observed between HLA-DQ antigen type and DQwl antigen. A

对婴儿猝死综合征(S病、S病)从多个角度进行了研究，对其基本特征和发病机制知之甚少。关于HLAs与各种疾病的相关性已有大量报道，但尚未见有关SIDs与HLA抗原关系的报道。因此，本研究对1995~1996年间收治的婴儿猝死综合征病例尸检标本进行了HLADQα、HLADQB1和HLADRB1基因分型，并鉴定了HLADQ·DR型，从而探讨了SIDs与HLADNA2之间的关系。所有病例的基因分型都是可能的。DQAlpha1.2、DQB1**0602和DRB1**15(1501、-02)在SIDS中的发生率较高。HLADQ抗原类型与DQw1抗原呈正相关。一个

项目成果

Saito, K., Takada, A., Murai, T., Murai, N.and Kuroda, N.: "Neonatal sepsis following umbilical infection : Autopsy report of an unexpected death case." Res.Pract.Forens.Med.39. 271-276 (1996)

Saito, K.、Takada, A.、Murai, T.、Murai, N. 和 Kuroda, N.：“脐带感染后的新生儿败血症：意外死亡病例的尸检报告。”

Hara, M., Saito, K., Takei, S., Kuroda, N,Yabe, K., Watanabe, H., Shinozuka, T.and Murai, T.: "HLA class II gene polymorpism of SIDS." Jpn J Legal Med.51, Suppl. 94-94 (1997)

Hara, M.、Saito, K.、Takei, S.、Kuroda, N、Yabe, K.、Watanabe, H.、Shinozuka, T. 和 Murai, T.：“SIDS 的 HLA II 类基因多态性”。

原 正昭: "乳幼児突然死症候群(SIDS)症例のHLA-DNAタイピング" 医学と生物学. 134. 117-121 (1997)

Masaaki Hara：“婴儿猝死综合症 (SIDS) 病例的 HLA-DNA 分型”医学与生物学，134. 117-121 (1997)。

原正昭: "乳幼児突然死症候群(SIDS)症例のHLA-DNAタイピング" 医学と生物学. 134・4(発表予定). (1997)

Masaaki Hara：“婴儿猝死综合症 (SIDS) 病例的 HLA-DNA 分型”《医学与生物学》134, 4（待出版）。