Investigation of Association between LDLR, ApE Polymorphisms Cardio Vascular with Sudden Death.

心血管LDLR、ApE多态性与猝死的关联性研究。

• 批准号: 10670400
• 负责人: HARA Masaaki
• 金额: $ 2.05万
• 依托单位: Saitama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670400/
• 关键词: LDLR polymorphism; Causes of death; Aortic diseases; Ischemic heart diseases; LDL receptor; Japanese; 多型; PCR; LDLR多型; 心・血管疾患; common mutation; 心・大動脈疾患

The association between LDLR polymorphism and some diseases was investigated on blood samples from 274 autopsy case. The frequency of LDLR AA type in natural death group was significantly higher than that in traumatic death group (P=0.0114). The differences between the frequency of LDLR A in cardiac and aortic disease group and that in head injury or vascular injury group were statistically significant (P<0.025). IN the group of aortic dissection and ischmic heart disease, the frequency of LDLR A was remarkably high. The genetic abnormalities of the LDL receptor may play some part in the etiology of cardiac and vascular disorders.

对274例尸检标本进行了LDLR基因多态性与某些疾病的相关性研究。自然死亡组LDLRAA型频率显著高于创伤死亡组(P=0.0114)。心脏和主动脉疾病组的LDLRA频率与颅脑损伤或血管损伤组比较差异有统计学意义(P&lt；0.025)。在主动脉夹层和缺血性心脏病组中，LDLRA的频率显著升高。低密度脂蛋白受体的遗传异常可能在心脏和血管疾病的病因中起一定作用。

项目成果

原 正昭、齋藤一之 他: "LDLR多型と心・血管疾患による突然死との関連性―加齢とDNA多型分布―"DNA多型. Vol.7. 258-264 (1999)

Masaaki Hara、Kazuyuki Saito 等：“LDLR 多态性与心血管和血管疾病引起的猝死之间的关系 - 衰老和 DNA 多态性分布 -”DNA 多态性。

Masaaki Hara, Kazuyuki Saito, Akira Kido, Kem Nemoto, Akira Itabasi, Aya Takada, Naoko Murai, Katsuhiro Yabe And Hiroshi Watanabe: "Association between LDLR Polymorphism in Japanese and the Causes of Death."Res.Pract.Forens.Med.. 41. 21-26 (1998)

Masaaki Hara、Kazuyuki Saito、Akira Kido、Kem Nemoto、Akira Itabasi、Aya Takada、Naoko Murai、Katsuhiro Yabe 和 Hiroshi Watanabe：“日本人 LDLR 多态性与死因之间的关联。”Res.Pract.Forens.Med..

Akira KIDO,Rie SUSUKIDA, et al: "AmpliType PM+DQA1Typing on Aged Seminal Stains"犯罪学雑誌. 65・2. 66-69 (1999)

Akira KIDO、Rie SUSUKIDA 等人：“AmpliType PM+DQA1Typing on Aged Seminal Stains”（犯罪学杂志）65・2（1999 年）。

Masaaki Hara, Kazuyuki Saito, Aya Takada, Naoko Murai, Katsuhiro Yabe, Hiroshi Watanabe, Ken Nemoto, Akira Itabasi, Akira Kido, Tatuya Shinozuka, Osamu Ohue and Tatsuya Murai: "Investigation of Association between LDLR Polymorphism and Cardio-or Cerebro V

Masaaki Hara、Kazuyuki Saito、Aya Takada、Naoko Murai、Katsuhiro Yabe、Hiroshi Watanabe、Ken Nemoto、Akira Itabasi、Akira Kido、Tatuya Shinozuka、Osamu Ohue 和 Tatsuya Murai：“LDLR 多态性与心脑 V 之间关联的调查

原 正昭 他: "LDLR多型と心・血管疾患による突然死との関連性" 第7回日本DNA多型学会. 発表. (1998)

Masaaki Hara 等人：“LDLR 多态性与心血管和血管疾病引起的猝死之间的关系”，日本 DNA 多态性协会第七届年会演讲（1998 年）。