Study on injury and remodeling the lung

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1)In vivo experiments(1)An Administration of niacin or nicotinamide inhibited oxidant-induced acute lung injury.(2)Elastase induced detachment of airway epithelium, and SLPI protected the cells from the detachment.(3)Neutrophil sequestration induced by G-CSF did not produce acute inflammation in the lung.(4)P-selectin antagonist inhibited acute lung inflammation induced by LPS.2)In vitro experiments(1)Oxidant induced necrosis and/or apoptosis in the airway epithelium, and these effects ware in dose-and time-dependent fashion.(2)TNF alpha induced apoptosis in the lung fibroblasts.(3)Depletion of cystine induced apoptosis in the lung fibroblasts and airway epithelium. These findings suggest that intra-celluar reactive oxygen may be associated with signal transduction of apoptosis.