Study of erectile dysfunction with penile vascular changes in hypertension patients

在高血压患者中，各种血管床中的小动脉经历增加阻力的结构变化。为了评估阴茎是否存在伴随高血压的差异性结构变化，我们首先确定成年自发性高血压大鼠（SHR）和Sprague -道利（SD）大鼠阴茎和后肢血管床中基于结构的血管阻力特性。在麻醉的SHR中，阴茎和后肢血管被分离和灌注，诱导最大扩张，并产生流量-压力评估和β 1-肾上腺素受体激动剂浓度-响应曲线。无论是基线和最大的收缩反应是相似的，在两个床的每一个应变，和整体的最大结构为基础的血管阻力在SHR高于SD rates.Our数据表明，阴茎血管是不保护的结构变化发生在其他血管床的高血压。似乎没有一个潜在的功能控制机制，保护阴茎血管系统的结构变化，可能有负面影响阴茎血流。

In hypertension patients, small arteries in a variety of vascular beds undergo structural changes that increase resistance. To assess whether there are differential structural changes in the penis that accompany hypertension, we began with determining structurally - based vascular resistance properties in penile and hindlimb vascular beds of adult spontaneously hypertensive rats (SHR) and Sprague - Dawley (SD)rats.In anesthetized SHR, the penile and hindlimb vasculature were isolated and perfused, maximum dilatation was induced, and a flow-pressure assessment and □1- adrenoceptor agonist concentration - response curves were generated. Both the baseline and maximum constrictor responses were similar in the two beds of each strain, and overall the maximum structurally-based vascular resistance in SHR was higher than in SD rats.Our data suggests that the penile vasculature is not protected from the structural changes that take place in the other vascular beds in hypertension. There does not appear to be an underlying functional control mechanism that protects the penile vasculature from structural changes that may have a negative impact on penile blood flow.