Enhacement of the effects of an angiogenesis inhibitor on murine tumors by hyperthermia

通过热疗增强血管生成抑制剂对小鼠肿瘤的作用

• 批准号: 07671033
• 负责人: TANAKA Yoshimasa
• 金额: $ 1.47万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671033/
• 关键词: Experimenta tumor; Inhibitor of angiogrnesis; Heat treatment; 温熱効果; マウス実験腫瘍

We investigated the effect of angiogenesis inhibitors (FR-118487 and TNP-470) on two murine tumors (FM3A, SCC-7) with and without hyperthermia. When angiogenesis inhibitors were adminstered immediately after tumor implantations there was no tumor growth. As the tumor diameter increased, the antitumor effect of inhibitors decreased. When FR-I 18487 was combined with hyperthermia, the antitumor effect was potentiated. This study suggested that angiogenesis inhibitors show their maximal effect against small tumors and have increased activity when combined with hyperthermia.

我们研究了具有和不含超热性的两种鼠肿瘤（FM3A，SCC-7）对两种鼠肿瘤（FM3A，SCC-7）的血管生成抑制剂（FR-118487和TNP-470）的影响。当肿瘤植入后立即将血管生成抑制剂吞噬时，没有肿瘤生长。随着肿瘤直径的增加，抑制剂的抗肿瘤作用减少。当Fr-I 18487与高温结合时，抗肿瘤效应被增强。这项研究表明，血管生成抑制剂对小肿瘤表现出最大作用，并且与高温结合时具有增加的活性。

项目成果

Takashi Murata, Valentina V.Ostapenko, Kiyoshi Akagi, Masahiro Imamura, Reiko Nasu, Hiroyuki Kimura, Yoshimasa Tanaka: "Relevance of a new impedance matching, or subtrap method, for the reduction of paiin during hyperthermia" ACTA Oncologica. 37. 485-488

Takashi Murata、Valentina V.Ostapenko、Kiyoshi Akagi、Masahiro Imamura、Reiko Nasu、Hiroyuki Kimura、Yoshimasa Tanaka：“新的阻抗匹配或 subtrap 方法对于减少热疗期间疼痛的相关性”ACTA Oncologica。

Reiko Nasu, Hiroyuki Kimura, Kiyoshi Akagi, Takashi Murata, Yoshimasa Tanaka.: "Blood flow influences vascular growth during tumor angiogenesis." British Journal of Cancer. 79. 780-786 (1999)

Reiko Nasu、Hiroyuki Kimura、Kiyoshi Akagi、Takashi Murata、Yoshimasa Tanaka：“血流影响肿瘤血管生成过程中的血管生长。”

Reiko Nasu: "Blood flow influences vascular growth during tumour angiogenesis" British Journal of Cancer. 79. 780-786 (1999)

Reiko Nasu：“血流影响肿瘤血管生成过程中的血管生长”英国癌症杂志。

Takashi Murata, Kiyoshi Akagi, Masahiro Imamura, Reiko Nasu, Hiroyuki Kimura, Kenji Nagata, Yoshimasa Tanaka: "Studies on the effectiveness of hyperthermia combined with arterial arterial therapeutic blockage in the treatment of tumors Part 3. Clinical st

Takashi Murata、Kiyoshi Akagi、Masahiro Imamura、Reiko Nasu、Hiroyuki Kimura、Kenji Nagata、Yoshimasa Tanaka：“热疗联合动脉动脉阻断治疗肿瘤的有效性研究第 3 部分：临床研究

Shigeki Ikeda: "Enhancement of effect of an angiogenesis inhibitor on murine fumor by hyperthermia" Oncology Reports. 5. 181-184 (1998)

Shigeki Ikeda：“通过热疗增强血管生成抑制剂对小鼠肿瘤的作用”肿瘤学报告。