Enhacement of the effects of an angiogenesis inhibitor on murine tumors by hyperthermia
Enhacement of the effects of an angiogenesis inhibitor on murine tumors by hyperthermia
批准号:
07671033
负责人:
TANAKA Yoshimasa
金额:
$1.47万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1995
资助国家:
日本
项目状态:
已结题
起止时间:
1995 至 1996
中文摘要
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英文摘要
We investigated the effect of angiogenesis inhibitors (FR-118487 and TNP-470) on two murine tumors (FM3A, SCC-7) with and without hyperthermia. When angiogenesis inhibitors were adminstered immediately after tumor implantations there was no tumor growth. As the tumor diameter increased, the antitumor effect of inhibitors decreased. When FR-I 18487 was combined with hyperthermia, the antitumor effect was potentiated. This study suggested that angiogenesis inhibitors show their maximal effect against small tumors and have increased activity when combined with hyperthermia.
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Takashi Murata, Valentina V.Ostapenko, Kiyoshi Akagi, Masahiro Imamura, Reiko Nasu, Hiroyuki Kimura, Yoshimasa Tanaka: "Relevance of a new impedance matching, or subtrap method, for the reduction of paiin during hyperthermia" ACTA Oncologica. 37. 485-488
Takashi Murata、Valentina V.Ostapenko、Kiyoshi Akagi、Masahiro Imamura、Reiko Nasu、Hiroyuki Kimura、Yoshimasa Tanaka:“新的阻抗匹配或 subtrap 方法对于减少热疗期间疼痛的相关性”ACTA Oncologica。
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Reiko Nasu, Hiroyuki Kimura, Kiyoshi Akagi, Takashi Murata, Yoshimasa Tanaka.: "Blood flow influences vascular growth during tumor angiogenesis." British Journal of Cancer. 79. 780-786 (1999)
Reiko Nasu、Hiroyuki Kimura、Kiyoshi Akagi、Takashi Murata、Yoshimasa Tanaka:“血流影响肿瘤血管生成过程中的血管生长。”
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Reiko Nasu: "Blood flow influences vascular growth during tumour angiogenesis" British Journal of Cancer. 79. 780-786 (1999)
Reiko Nasu:“血流影响肿瘤血管生成过程中的血管生长”英国癌症杂志。
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Shigeki Ikeda: "Enhancement of effect of an angiogenesis inhibitor on murine fumor by hyperthermia" Oncology Reports. 5. 181-184 (1998)
Shigeki Ikeda:“通过热疗增强血管生成抑制剂对小鼠肿瘤的作用”肿瘤学报告。
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Takashi Murata, Kiyoshi Akagi, Masahiro Imamura, Reiko Nasu, Hiroyuki Kimura, Kenji Nagata, Yoshimasa Tanaka: "Studies on the effectiveness of hyperthermia combined with arterial arterial therapeutic blockage in the treatment of tumors Part 3. Clinical st
Takashi Murata、Kiyoshi Akagi、Masahiro Imamura、Reiko Nasu、Hiroyuki Kimura、Kenji Nagata、Yoshimasa Tanaka:“热疗联合动脉动脉阻断治疗肿瘤的有效性研究第 3 部分:临床研究
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共 8 条
Development of cell preparations and high/low molecular-weight therapeutics that exhibit synergistic effects with PD-1 immune checkpoint antibodies
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Study on generation mechanism of substorm by using high-resolution auroral data
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Identification of tumor antigens by the use of human γδ TCR tetramers
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Pattern recognition by human γδ T cells and innate immunity.
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Measurement of extracellular pH decrease cased by hyperthermiaand drugs on tumor cells.
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Roles of DNA topoisomerase II in the development of the cellular slime molds.
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Measurement of pH in tumor tissue by 31P-MRS and microelectrode after glucose injection.
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Effect of mitochondrial genes on development and differentiation in the cellular slime molds.
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资助金额:$1.34万
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依托单位:
Radiosensitizing effect by increase of tumor pO_2 using Perfluorochemicals.
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依托单位:
The development of a new liver function test using the labeled asialoglycoprotein.
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项目类别:Grant-in-Aid for General Scientific Research (C)
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负责人:TANAKA Yoshimasa
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依托单位: