A Study about Effects of Anesthesia on Hepatic Circulation, Oxygen Metabolism, Intra-cellular Ca^<++> Mobilization and Liver Injury
麻醉对肝循环、氧代谢、细胞内Ca^<>动员及肝损伤影响的研究
基本信息
- 批准号:07671683
- 负责人:
- 金额:$ 0.32万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1995
- 资助国家:日本
- 起止时间:1995 至 1996
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1) Effects of halothane, isoflurane and sevoflurane on hepatic blood flow (HBF), oxygen metabolism (HOM) and energy carge (HEC) were investigated in mongrel dogs during hypoxemia or hepatologectomy. Isoflurane and sevoflurane maintained HBF,HOM and HEC better than halothane. These results indicate that liver injury based on imbalance of HOM would not be induced by isoflurane or sevoflurane except under severe hypoxic condition. 2) HBF and HOM were also investigated in beagles during cardiopulmonary bypass (CPB) with fentanyl anesthesia. Increasing the dose of fentanyl to 50 mug/kg/h during CPB decreased HBF and suppressed HOM,while 10mug/kg/h of fentanyl produced minimal effects on HBF and HOM,so far as perfusion rate was within 80% of aortic blood flow of pre-CPB value. A large dose of fentanyl during CPB combined with hypoxemia could possibly cause liver injury. 3) Organ perfusion is regulated by contraction and relaxation of smooth muscles around vessels. In generally speaking, this regulation would be influenced by nitric oxide (NO) production and formation, and also same in hepatic sinusoids. In the liver, NO synthesized by constitutive NO synthase (cNOs) was assumed to control hepatic sinusoidal micro-circulation. CNOS requires Ca^<++> ion during synthesis of NO and so has tight correlation with intra-cellular free Ca^<++> concentration. We established a new highly sensitive method for measurement of chemical compounds which is related to cNOS-dependent NO in whole blood at steady state, and are investigating the relationship among NO production, intra-cellular Ca^<++> mobilization and decrease of HBF by anesthetics.
1)本文观察了氟烷、异氟醚和七氟醚对低氧血症和肝切除犬肝血流量(HBF)、氧代谢(HOM)和能量负荷(HEC)的影响。异氟烷和七氟烷维持HBF、HOM和HEC的效果优于氟烷。这些结果表明,除非在严重缺氧条件下,异氟醚或七氟醚不会引起基于HOM失衡的肝损伤。2)在体外循环(CPB)期间,芬太尼麻醉的比格犬也进行了HBF和HOM的研究。在CPB期间增加芬太尼剂量至50 μ g/kg/h可降低HBF并抑制HOM,而10 μ g/kg/h芬太尼对HBF和HOM的影响最小,只要灌注率在CPB前主动脉血流量值的80%以内。体外循环期间大剂量芬太尼合并低氧血症可能会导致肝脏损伤。3)器官灌注通过血管周围平滑肌的收缩和舒张来调节。一般来说,这种调节受一氧化氮(NO)产生和形成的影响,在肝窦中也是如此。在肝脏中,由组成型NO合酶(cNOs)合成的NO被认为控制肝窦微循环。CNOS在合成NO过程中需要Ca^++,因此与细胞内游离Ca^++浓度密切相关。我们建立了一种新的高灵敏度的方法,用于测量稳态时全血中与cNOS依赖性NO相关的化合物,并正在研究NO产生、细胞内Ca^++动员和麻醉剂引起的HBF减少之间的关系。
项目成果
期刊论文数量(17)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sonoda, M.Miyazaki, T.et al: "Measurements of the nitric-oxide related compounds in whole blood and their metabolic fate" Magnetic Resonance in Medicine. Vol.8. 162-165 (1997)
Sonoda、M.Miyazaki、T.et al:“全血中一氧化氮相关化合物的测量及其代谢命运”医学中的磁共振。
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
松本延幸 ほか: "麻酔と肝臓……麻酔が肝血流に及ぼす影響" Anesthesia Today. 5. 4-13 (1996)
Nobuyuki Matsumoto 等人:“麻醉与肝脏……麻醉对肝血流的影响”《今日麻醉》5. 4-13 (1996)。
- DOI:
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- 影响因子:0
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Sonoda, M.Miyazaki, T.et al: "A study on the highly sensitive measurements of the nitric-oxide related compounds in blood samples" Magnetic Resonance in Medicine. Vol.7. 188-191 (1996)
Sonoda, M.Miyazaki, T.等人:“对血液样本中一氧化氮相关化合物进行高灵敏度测量的研究”医学磁共振。
- DOI:
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- 影响因子:0
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松本延幸: "図説最新麻酔学シリーズ第3巻 麻酔中の患者の生理学 肝機能" メジカルビュー社, 262(うち105-115) (1996)
Nobuyuki Matsumoto:“图解最新麻醉学系列第 3 卷:麻醉下患者的生理学肝功能”Medical View Publishing,262(其中 105-115)(1996 年)
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- 影响因子:0
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薗田勝、宮崎孝 ほか: "全血中NO^-関連化合物の測定とその動態に関する研究" 磁気共鳴と医学. 8. 162-165 (1997)
Masaru Sonoda、Takashi Miyazaki 等人:“全血中 NO 相关化合物的测量及其动力学研究”《磁共振与医学》8. 162-165 (1997)。
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MATSUMOTO Nobuyuki其他文献
MATSUMOTO Nobuyuki的其他文献
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{{ truncateString('MATSUMOTO Nobuyuki', 18)}}的其他基金
Cooling of a massive pendulum to its ground state for test of generalized uncertainty principle
将大摆冷却至基态以测试广义不确定性原理
- 批准号:
15H05444 - 财政年份:2015
- 资助金额:
$ 0.32万 - 项目类别:
Grant-in-Aid for Young Scientists (A)
Progressive study of the Takao mandala based on the optical survey
基于光学测量的塔尾坛城进展研究
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23320036 - 财政年份:2011
- 资助金额:
$ 0.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
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