3D analysis of regional hepatic blood flow by means of hepatic imaging using monochromatic synchrotron radiation

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3D analysis of regional hepatic blood flow was performed by means of hepatic flow imaging using monochromatic synchrotron radiation. Our results showed that micro-CT enables the evaluation of microanastomosis between small arteries and portal veins as well as the degree of neovascularization. This fact may help elucidate the cause of early enhancing hepatic pseudolesions observed in contrast-enhanced dynamic CT or MRI. Intrahepatic distribution of Gd-EOB-DTPA as a hepatocyte-specific contrast agent was also assessed by using normal and NASH model mouse. In normal mouse, predominant uptake of Gd-EOB-DTPA in the hepatocyte was observed. In NASH model mouse, uptake of Gd-EOB-DTPA gradually decreased, according to the progression of hepatic fibrosis, suggesting the relationship between hepatocyte function and dynamic changes of hepatic blood flow. Regarding the Gd deposition in the liver, Gd deposition in renal dysfunction model rat was minimal. However, Gd deposition was increased in hepatorenal dysfunction model rat, indicating the increased risk of deterioration of liver function.