The Pathogenic effect of free radical in the inner ear and its cyrative methods

自由基在内耳的致病作用及其消除方法

• 批准号: 07671876
• 负责人: YAMANE Hideo
• 金额: $ 1.41万
• 依托单位: OSAKA CITY UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671876/
• 关键词: Inner ear; Free radical; Aminoglycoside; Nitric oxide; Cochlea; Blood Flow; BRM

We investigated whether the inner ear is under the circumstance where free radical is induced under some pathological conditions, and we got the following results.#1.Aminiglycoside derivatives can dose-dependently induce free radical at the cell membrane of outer hair cells in the guinea pig cochlea and these free raidcals are locally dismutated.#2.The blood flow of the cochlear lateral wal is regulated by nitric oxide which is produced in the endothlium of strial capillary or spiral vessel.#3.The residential macrophages were recognized on the membrane of the scala tympani. These macrophages have a possibility to protcet the inner ear by producign free radiocals against pathogens.#4.Biological response modifier (BRM) could indece the early emergence of macrophages in the inner ear which means that the inner ear can be an affected organ by artificial manner to infection process.

我们研究了内耳在某些病理条件下是否处于自由基诱导的环境中，并得到以下结果。1.氨基糖苷衍生物能剂量依赖性地诱导豚鼠耳蜗外毛细胞膜上的自由基，这些自由基被局部歧化。2.耳蜗外侧壁的血流受毛细血管或螺旋血管内皮细胞产生的一氧化氮的调节。3.在鼓阶的膜上识别出了驻留的巨噬细胞。这些巨噬细胞有可能通过产生抵抗病原体的游离放射性物质来保护内耳。4.生物反应调节剂（BRM）能诱导内耳巨噬细胞的早期出现，说明内耳可以通过人工方式成为感染过程的一个受累器官。

项目成果

山根 英雄: "NO : nitric oxide" Equlibrium Res. 56(4). 398-399 (1997)

Hideo Yamane：“NO：一氧化氮”平衡研究 56(4) (1997)。

H.Yamane, Y.Nakai, T.Sakurai, K.Konishi, A.Hakuba, M.Igarashi :: Differencer in recovery process of postural control in patients with unilateral anb bilateral labyrinthine deficits.Postural reflex and body equilibrium IV, 104-112 (1995)

H.Yamane, Y.Nakai, T.Sakurai, K.Konishi, A.Hakuba, M.Igarashi :: 单侧和双侧迷路缺陷患者姿势控制恢复过程的差异。姿势反射和身体平衡 IV, 104-

H.Yamane: "In vivo regeneration of vestibular hair cells of guineupig" Acta Otolaryngol(Stockh)Suppl. 520. 174-177 (1995)

H.Yamane：“豚鼠前庭毛细胞的体内再生”Acta Otolaryngol（Stockh）Suppl。

H.Yamane, T.Nakagawa, H.Iguchi, S.Shibata, M Takayama, K.Nishimura, Y.Nakai :"In vivo regeneration of vestibular hair cells of guinea pig." Acta Otolaryngol (stockh) Suppl.520. 174-177 (1995)

H.Yamane、T.Nakakawa、H.Iguchi、S.Shibata、M Takayama、K.Nishimura、Y.Nakai：“豚鼠前庭毛细胞的体内再生”。

H.Yamane, Y.Nakai, M.Takayama, H.Iguchi, T.Nakagawa, A.Kojima: "Appearance of free radicals in the guinea pig inner ear after noise-Induced acoustic trauma." Eur Arch Otorhinolaryngol. 252. 504-508 (1995)

H.Yamane、Y.Nakai、M.Takayama、H.Iguchi、T.Nakakawa、A.Kojima：“噪声引起的声损伤后豚鼠内耳中自由基的出现。”