Histologic and Hydrodynamic Evaluation of Blood Flow for Scintigraphic Detection of Malignant Tumor of the Head and Neck.

头颈部恶性肿瘤闪烁显像检测中血流的组织学和流体动力学评估。

• 批准号: 07672052
• 负责人: SATO Tsuyoshi
• 金额: $ 1.28万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672052/
• 关键词: Scintigraphy; Early image; Malignant tumor; Blood flow; Head and Neck; Scintigrashy; Blood flow

In the experiment with animals, Japan white rabbits transplanted with VX2 carcinoma in the right femoral regionwere examined histologically, angiographically and hydrodynamically. The tumor blood vessel became rich in accordance with tumor growth and the blood flow rate and the volume of the blood flow of the right femoral artery in the tumor side was approximately twice or three times as much as that in the control side (left femoral artery) by means of the ultrasonic blood flow meter (5 MHz). In the clinical examination, 117 patients with oral cancer were examined scintigraphically and histopathologically. Tumor blood flow was estimated scintigraphically immediately after administration of <@D199m@>D1Tc-HMDP.Radioactivity of venous phase (30 to 40 seconds after administration) and blood pool phase (1 to 3 minutes) were observed. Radioactive ratios of tumor to the control region in both phases were calculated ; venous ratio (VR), blood pool ratio (BPR). Early image with <@D199m@>D1Tc-HMDP (early image) was obtained 5 minutes after administration and the image with <@D167@>D1Ga-citrate (Ga-image) was obtained 3 days after administration. Tumor vascular patterns were classified histopathologically into three groups ; rich, intermediate and poor. VR,BPR,early image, Ga-image, vascular pattern and tumor size were compared each other. Poor vascular pattern showed small VR (M(]SY.+-。[)SD=0.97(]SY.+-。[)0.08) and BPR (1.02(]SY.+-。[)0.04). Rich vascular pattern showed large VR (1.39(]SY.+-。[)0.01) and BPR (1.31(]SY.+-。[)0.16). Positive early image was predominant among large VR (78%) and BPR (100%). Tumors of under 3 cm in size showed that 65% of them belonged to intermediate or rich vascular pattern and positive early image reflected tumor blood flow. These results intimated the improvement of detecting ratio by combining early image (blood flow image) with delayd image.

在动物实验中，对日本白色家兔右股部移植VX 2癌进行了组织学、血管造影和水动力学检查。肿瘤血管随着肿瘤的生长而丰富，用超声波血流计（5 MHz）测定，肿瘤侧的右股动脉的血流速度和血流量约为对照侧（左股动脉）的2倍或3倍。在临床检查中，对117例口腔癌患者进行了组织病理学检查。给药后立即用放射免疫法测定肿瘤血流量，观察静脉相（给药后30 ~ 40秒）和血池相（1 ~ 3分钟）的放射性。计算两个时相肿瘤与对照区的放射性比值：静脉比值（VR）、血池比值（BPR）。在给药后5分钟获得<@D199m@> D1 Tc-HMDP的早期图像（早期图像），并且在给药后3天获得<@D167@> D1 Ga-柠檬酸盐的图像（Ga-图像）。组织病理学将肿瘤血管类型分为三组：丰富、中等和较差。比较VR、BPR、早期图像、GA图像、血管形态及肿瘤大小。血管形态差，VR小（M（）SY. ±. [)SD=0.97（±）SY. [）0.08）和BPR（1.02（]SY. ±. [）0.04）。丰富的血管型显示大的VR（1.39 ± 0.01）。[）0.01）和BPR（1.31（]SY. ±. [）0.16）。早期影像阳性主要见于大VR（78%）和BPR（100%）。3cm以下肿瘤65%为中等或富血管型，早期阳性图像反映肿瘤血流。这些结果表明，早期图像（血流图像）与延迟图像相结合可提高检出率。

项目成果

T.Sato et al: "Interpretation of scintigraphic findings on the basis of histological vascular system for the detection of malignant twnor" Oral Orcology. IV(A). 75-78 (1995)

T.Sato 等人：“根据组织学血管系统对闪烁扫描结果的解释，用于检测恶性肿瘤” Oral Orcology。

T.Sato,et al.: "Interpretation of scintigraphic findings on the basis of histlogical vascular system for the detection of malignant tumor." Oral Oncology. IV"A". 75-78 (1995)

T.Sato 等人：“根据组织学血管系统解释闪烁扫描结果，以检测恶性肿瘤。”

SATO,T., HAYAKAWA,K., MIYAHARA,M., KAWASHIMA,K., NOIKURA,T., YAMASHITA,S.: "Scintigraphic detection of oral cancer with early bone scintigraphy." Oral Radiology. (1997)

SATO,T.、HAYAKAWA,K.、MIYAHARA,M.、KAWASHIMA,K.、NOIKURA,T.、YAMASHITA,S.：“利用早期骨闪烁扫描技术检测口腔癌。”

T.Sato,et al: "Scintigraphic detection of oral cancer with early bone scintigraphy" Oral Radiology. (1997)

T.Sato 等人：“用早期骨闪烁扫描技术检测口腔癌”口腔放射学。