Scintigraphic imaging system of micro-metastasis of lymph node with pinhole collimator

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Expression of transport proteins of nuclear agents on cell membrane was evaluated immunohistochemically by using animal models with squamous cell carcinoma. The expression of transport proteins was found distinctly on the tumor cell membrane and showed a clear correlation with the accumulation of nuclear agents in tumor cells. (2) Scintigraphic imaging of lymph node model was done with pinhole collimators of 5mm and 7mm in hole size and the spatial resolution was about 5mm. This result showed a possibility that scintigraphic imaging with pinhole collimator could detect a micro metastasis in lymph nodes of over 10mm in size.