Characterization of the dark metabolome of eukaryotic cells

真核细胞暗代谢组的表征

• 批准号: DP220101689
• 负责人: Prof Malcolm McConville
• 金额: $ 55.8万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-12-31 至 2026-12-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101689
• 关键词: Characterization; dark; metabolome; eukaryotic; cells

The project aims to investigate the full metabolic potential of a group of eukaryotic organisms using advanced analytical and computational techniques. It will identify novel metabolites and enzyme activities that are currently not predicted from genome annotations. Expected outcomes of the project include the delineation of new metabolic processes that are common to all eukaryotes, the characterization of new enzymes families, and the generation of comprehensive metabolic databases. An improved understanding of cellular metabolism will provide direct benefits in biotechnology, food production, environmental monitoring and the diagnosis and treatment of human metabolic and infectious diseases.

该项目旨在利用先进的分析和计算技术研究一组真核生物的全部代谢潜力。它将识别目前无法从基因组注释中预测的新代谢物和酶活性。该项目的预期成果包括描述所有真核生物共有的新的代谢过程，新的酶家族的特征，以及产生全面的代谢数据库。更好地了解细胞代谢将在生物技术、食品生产、环境监测以及人类新陈代谢和传染病的诊断和治疗方面提供直接好处。